Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt.
Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City 11231, Cairo, Egypt; Department of Biochemistry, Faculty of Pharmacy, Egyptian Russian University, Badr City 11829, Cairo, Egypt.
Pathol Res Pract. 2023 Jun;246:154529. doi: 10.1016/j.prp.2023.154529. Epub 2023 May 11.
Globally, esophageal cancer (EC) is the 6th leading cause of cancer-related deaths and the second deadliest gastrointestinal cancer. Multiple genetic and epigenetic factors, such as microRNAs (miRNAs), influence its onset and progression. miRNAs are short nucleic acid molecules that can regulate multiple cellular processes by regulating gene expression. Therefore, EC initiation, progression, apoptosis evasions, invasion capacity, promotion, angiogenesis, and epithelial-mesenchymal transition (EMT) enhancement are associated with miRNA expression dysregulation. Wnt/-catenin signaling, Mammalian target of rapamycin (mTOR)/P-gp, phosphoinositide-3-kinase (PI3K)/AKT/c-Myc, epidermal growth factor receptor (EGFR), and transforming growth factor (TGF)-β signaling are crucial pathways in EC that are controlled by miRNAs. This review was conducted to provide an up-to-date assessment of the role of microRNAs in EC pathogenesis and their modulatory effects on responses to various EC treatment modalities.
全球范围内，食管癌（EC）是癌症相关死亡的第 6 大主要原因，也是第二大致命的胃肠道癌症。多种遗传和表观遗传因素，如 microRNAs（miRNAs），影响其发生和进展。miRNAs 是短的核酸分子，可以通过调节基因表达来调节多个细胞过程。因此，miRNA 表达失调与 EC 的起始、进展、凋亡逃逸、侵袭能力、促进、血管生成和上皮-间充质转化（EMT）增强有关。Wnt/-catenin 信号、雷帕霉素靶蛋白（mTOR）/P-gp、磷酸肌醇 3-激酶（PI3K）/AKT/c-Myc、表皮生长因子受体（EGFR）和转化生长因子（TGF）-β信号是受 miRNAs 调控的 EC 中的关键途径。本综述旨在提供对 miRNAs 在 EC 发病机制中的作用及其对各种 EC 治疗方式反应的调节作用的最新评估。
