Department of Biochemistry and Biotechnology, Faculty of Pharmacy, Heliopolis University, Cairo 11785, Egypt.
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt.
Life Sci. 2023 Jun 1;322:121667. doi: 10.1016/j.lfs.2023.121667. Epub 2023 Apr 4.
Gastric cancer (GC) is 4th in incidence and mortality rates globally. Several genetic and epigenetic factors, including microRNAs (miRNAs), affect its initiation and progression. miRNAs are short chains of nucleic acids that can regulate several cellular processes by controlling their gene expression. So, dysregulation of miRNAs expressions is associated with GC initiation, progression, invasion capacity, apoptosis evasions, angiogenesis, promotion and EMT enhancement. Of important pathways in GC and controlled by miRNAs are Wnt/β-catenin signaling, HMGA2/mTOR/P-gp, PI3K/AKT/c-Myc, VEGFR and TGFb signaling. Hence, this review was conducted to review an updated view of the role of miRNAs in GC pathogenesis and their modulatory effects on responses to different GC treatment modalities.
胃癌（GC）是全球发病率和死亡率第 4 位的癌症。包括 microRNAs（miRNAs）在内的多种遗传和表观遗传因素影响其发生和发展。miRNAs 是短链核酸，可以通过控制基因表达来调节多种细胞过程。因此，miRNAs 表达的失调与 GC 的发生、进展、侵袭能力、凋亡逃逸、血管生成、促进和 EMT 增强有关。受 miRNAs 调控的 GC 中的重要途径有 Wnt/β-catenin 信号通路、HMGA2/mTOR/P-gp、PI3K/AKT/c-Myc、VEGFR 和 TGFβ 信号通路。因此，本综述旨在综述 miRNAs 在 GC 发病机制中的作用及其对不同 GC 治疗方式反应的调节作用的最新观点。
