Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
R&D Center for Advanced Pharmaceuticals & Evaluation, Korea Institute of Toxicology (KIT), Daejeon, 34114, Republic of Korea.
Adv Mater. 2023 Sep;35(36):e2301098. doi: 10.1002/adma.202301098. Epub 2023 Jul 27.
Blood vessel anastomosis by suture is a life-saving, yet time-consuming and labor-intensive operation. While suture-less alternatives utilizing clips or related devices are developed to address these shortcomings, suture anastomosis is still overwhelmingly used in most cases. In this study, practical "less-suture" strategies are proposed, rather than ideal "suture-less" methods, to reflect real-world clinical situations. In the case of rat artery (d = 0.64 mm) anastomosis, the less-suture anastomosis involves the application of thin, adhesive, transparent, and self-wrapping films to the site. This surprisingly reduces the number of stitches required from ten (without films) to four (with films), saving 27 min of operating time per vessel. Furthermore, the decreased number of stitches largely alleviates fibrosis-mediated wall-thickening. Thus, a less-suture strategy is particularly useful for anastomosis of multiple vessels in emergency conditions and small-diameter vessels.
血管缝合吻合术是一种救生但耗时耗力的操作。虽然已经开发出无缝线的替代方法，如使用夹子或相关器械，但缝合吻合术在大多数情况下仍然被广泛应用。在本研究中，提出了实际的“少缝线”策略，而不是理想的“无缝线”方法，以反映真实的临床情况。在大鼠动脉（d = 0.64 毫米）吻合的情况下，少缝线吻合术涉及在吻合部位应用薄的、粘性的、透明的和自包裹的膜。令人惊讶的是，这将所需缝线的数量从十个（无膜）减少到四个（有膜），每个血管节省了 27 分钟的手术时间。此外，缝线数量的减少在很大程度上减轻了纤维化介导的壁增厚。因此，少缝线策略特别适用于紧急情况下和小直径血管的多血管吻合。
