Spine Center and Department of Orthopaedic Surgery, Seoul National University College of Medicine and Seoul National University Bundang Hospital, Seongnam, Korea.
Department of Orthopaedic Surgery, Korea University Ansan Hospital, Ansan, 123, Jeokgeum-Ro, Danwon-Gu, Ansan-Si, Gyeonggi-Do, 15355, Republic of Korea.
Sci Rep. 2023 May 17;13(1):8013. doi: 10.1038/s41598-023-34828-y.
We aimed to investigate how underweight affects the incidence of fractures, as well as the influence of cumulative, longitudinal periods of low body mass index (BMI) and changes in body weight on fracture development. Data on adults aged 40-year and over who had three health screenings between January 1, 2007, and December 31, 2009 were used to determine the incidence of new fractures. The hazard ratios (HRs) for new fractures depending on BMI, total cumulative number of underweight, and weight change over time were calculated using Cox proportional hazard analysis. In this study, 15,955 (2.8%) of the 561,779 adults were diagnosed with fractures more than once over three health examinations. The fully adjusted HR for fractures in underweight individuals was 1.173 (95% Confidence interval [CI] 1.093-1.259). Underweight individuals diagnosed only once, twice, or three times had an adjusted HR of 1.227 (95%CI 1.130-1.332), 1.174 (95%CI 1.045-1.319), and 1.255 (95%CI 1.143-1.379), respectively. Although the adjusted HR was higher in adults who consistently had underweight (HR; 1.250 [95%CI 1.146-1.363]), those with underweight had an increased risk of fractures regardless of weight change (HR; 1.171 [95%CI 1.045-1.312], and 1.203[95%CI 1.075-1.346]). Underweight is a risk factor for fractures in adults over the age of 40 years, even if they returned to normal weight.
我们旨在研究体重过轻如何影响骨折的发生率，以及累积的、纵向的低体重指数（BMI）期和体重变化对骨折发展的影响。使用了 2007 年 1 月 1 日至 2009 年 12 月 31 日期间进行了三次健康筛查的年龄在 40 岁及以上的成年人的数据来确定新骨折的发生率。使用 Cox 比例风险分析计算了新骨折的 BMI、总消瘦次数和体重随时间变化的风险比（HR）。在这项研究中，561779 名成年人中有 15955 人（2.8%）在三次健康检查中被诊断出多次骨折。体重过轻个体的骨折风险的完全调整 HR 为 1.173（95%置信区间[CI] 1.093-1.259）。仅被诊断过一次、两次或三次体重过轻的个体的调整后 HR 分别为 1.227（95%CI 1.130-1.332）、1.174（95%CI 1.045-1.319）和 1.255（95%CI 1.143-1.379）。尽管持续体重过轻的成年人的调整后 HR 更高（HR；1.250 [95%CI 1.146-1.363]），但无论体重变化如何，体重过轻者都有骨折风险增加（HR；1.171 [95%CI 1.045-1.312]，1.203[95%CI 1.075-1.346]）。40 岁以上成年人体重过轻是骨折的一个危险因素，即使他们恢复到正常体重。
