植入皮肤源性前体细胞雪旺细胞可改善双侧海绵体神经损伤大鼠模型的勃起功能。

Implantation of skin-derived precursor Schwann cells improves erectile function in a bilateral cavernous nerve injury rat model.

作者信息

Ma Xiaolei, Yang Wende, Nie Pan, Zhang Zhenbin, Chen Zehong, Wei Hongbo

机构信息

Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600, Guangzhou, 510630, China.

出版信息

Basic Clin Androl. 2023 May 18;33(1):11. doi: 10.1186/s12610-023-00187-x.

BACKGROUND

This study was conducted to investigate the therapeutic potential of the skin-derived precursor Schwann cells for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerve injury.

RESULTS

The skin-derived precursor Schwann cells-treatment significantly restored erectile functions, accelerated the recovery of endothelial and smooth muscle tissues in the penis, and promoted nerve repair. The expression of p-Smad2/3 decreased after the treatment, which indicated significantly reduced fibrosis in the corpus cavernosum.

CONCLUSIONS

Implantation of skin-derived precursor Schwann cells is an effective therapeutic strategy for treating erectile dysfunction induced by bilateral cavernous nerve injury.