Al-Waili N S
Clin Exp Pharmacol Physiol. 1986 Mar;13(3):195-9. doi: 10.1111/j.1440-1681.1986.tb00337.x.
The effect of indomethacin suppositories on both acute urinary colic and urinary calculus, resistant or refractory to conventional therapy with analgesics and spasmolytics was investigated. Fifty-five patients with acute urinary colic refractory to treatment with repeated injections of antispasmodics and analgesics had dramatic or complete pain relief after receiving indomethacin suppositories (100 mg) (P less than 0.01). Fifteen of the 55 patients passed urinary stones within 30 days of treatment with indomethacin. Three out of 30 other patients with renal or ureteric stones were treated with indomethacin suppositories (100 mg) twice daily. Twenty-one of the 30 patients passed their stones within 30 days of treatment. It is concluded that indomethacin suppositories can relieve acute urinary colic resistant to treatment with analgesic/antispasmodic drugs, and facilitate expulsion of urinary calculi. The mechanism of action of indomethacin is discussed in terms of its analgesic and anti-inflammatory effects and its prostaglandin synthesis inhibition.
研究了消炎痛栓对急性肾绞痛和尿路结石的疗效，这些病例对使用镇痛药和解痉药的传统治疗有抵抗或难治性。55例经反复注射解痉药和镇痛药治疗无效的急性肾绞痛患者，在使用消炎痛栓（100毫克）后疼痛显著缓解或完全缓解（P<0.01）。55例患者中有15例在使用消炎痛治疗的30天内排出了尿路结石。另外30例肾或输尿管结石患者中有3例每天两次使用消炎痛栓（100毫克）进行治疗。30例患者中有21例在治疗的30天内排出了结石。结论是消炎痛栓可缓解对镇痛/解痉药物治疗有抵抗性的急性肾绞痛，并促进尿路结石的排出。从消炎痛的镇痛、抗炎作用及其对前列腺素合成的抑制作用方面讨论了其作用机制。
