韩国额颞叶痴呆伴语义障碍患者血浆中寡聚 TDP-43 增加。
Increased oligomeric TDP-43 in the plasma of Korean frontotemporal dementia patients with semantic dementia.
机构信息
Department of Bionano Technology, Bionano Research Institute, Gachon University, Gyeonggi-do, Republic of Korea.
Department of Neurology, Chung-Ang University Hospital, Seoul, Republic of Korea.
出版信息
Alzheimers Dement. 2023 Sep;19(9):4020-4027. doi: 10.1002/alz.13127. Epub 2023 May 18.
INTRODUCTION
Semantic dementia (SD) is a progressive neurodegenerative disease associated with impaired vocabulary that progresses to memory impairment. Post-mortem immunohistochemical analysis is the current reliable method of differentiating TDP-43 deposits in cortical tissue; no means of antemortem diagnosis exists in biofluids, let alone in plasma.
METHODS
Here the multimer detection system (MDS) was used to quantify the oligomeric TDP-43 (o-TDP-43) concentrations in plasma of Korean SD patients (n = 16, 6 male, 10 female, ages 59-87). The o-TDP-43 concentrations were compared with the total TDP-43 (t-TDP-43) concentrations quantified through conventional enzyme-linked immunosorbent assay (ELISA).
RESULTS AND DISCUSSION
Only MDS showed a significant increase in o-TDP-43 concentrations in the plasma of patients with SD compared to other neurodegenerative disorders and normal controls (p < 0.05). Based on these results, o-TDP-43 concentrations through the application of MDS may be a useful plasma biomarker in SD-FTD (frontotemporal dementia) diagnosis.
简介
语义性痴呆（SD）是一种进行性神经退行性疾病，与词汇障碍有关，并逐渐发展为记忆障碍。组织免疫化学分析是目前区分皮质组织中 TDP-43 沉积物的可靠方法；在生物液中，更不用说在血浆中，尚无生前诊断的方法。
方法
本研究使用多聚体检测系统（MDS）来量化韩国 SD 患者（n=16，6 男，10 女，年龄 59-87 岁）血浆中的低聚 TDP-43（o-TDP-43）浓度。通过常规酶联免疫吸附试验（ELISA）量化的总 TDP-43（t-TDP-43）浓度进行比较。
结果与讨论
只有 MDS 显示 SD 患者血浆中的 o-TDP-43 浓度与其他神经退行性疾病和正常对照组相比显著增加（p<0.05）。基于这些结果，通过 MDS 应用 o-TDP-43 浓度可能是 SD-FTD（额颞叶痴呆）诊断中有用的血浆生物标志物。
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