Centre for Dentistry, School of Medicine Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom.
PLoS One. 2023 May 18;18(5):e0285117. doi: 10.1371/journal.pone.0285117. eCollection 2023.
To investigate the association between denture wearing and airflow limitation in men in Northern Ireland enrolled in the Prospective Epidemiological Study of Myocardial Infarction (PRIME) study.
A case-control design was used to study partially dentate men. Cases were men aged 58-72 years who were confirmed as denture wearers. Controls were never denture wearers who were matched by age (± 1 month) and smoking habit to the cases. The men had a periodontal assessment and completed a questionnaire detailing their medical history, dental history and behaviours, social circumstances, demographic background and tobacco use. Physical examination and spirometry measurements of forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were also undertaken. Spirometry data for edentulous men who wore complete dentures were compared with that recorded for the partially dentate men studied.
There were 353 cases who were partially dentate and were confirmed denture wearers. They were matched for age and smoking habit to never denture wearer controls. The cases had an FEV1 that was on average 140 ml lower than the controls, p = 0.0013 and a 4% reduction in percent predicted FEV1, p = 0.0022. Application of the GOLD criteria indicated that 61 (17.3%) of the cases had moderate to severe airflow limitation compared with 33 (9.3%) of controls, p = 0.0051. Fully adjusted multivariable analysis showed that partially dentate men who were denture wearers were significantly more likely (p = 0.01) to have moderate to severe airflow reduction with an adjusted odds ratio (OR) of 2.37 (95% confidence intervals 1.23-4.55). In the 153 edentulous men studied moderate to severe airflow limitation was recorded in 44 (28.4%), which was significantly higher than in the partially dentate denture wearers (p = 0.017), and the men who had never worn a denture (p<0.0001).
Denture wearing was associated with an increased risk of moderate to severe airflow limitation in the cohort of middle-aged Western European men studied.
在北爱尔兰参加前瞻性心肌梗死（PRIME）研究的男性中，研究戴义齿与气流受限的关系。
采用病例对照设计研究部分缺牙男性。病例为年龄在 58-72 岁之间的已确诊为戴义齿者。对照组为从不戴义齿者，通过年龄（±1 个月）和吸烟习惯与病例相匹配。这些男性进行了牙周评估，并完成了一份详细记录其病史、牙科史和行为、社会环境、人口统计学背景和烟草使用情况的问卷。还进行了体格检查和用力呼气量一秒（FEV1）和用力肺活量（FVC）的肺活量测定。比较了戴全口义齿的无牙男性的肺活量数据与所研究的部分缺牙男性的记录。
共有 353 名部分缺牙且确认为戴义齿者的病例。他们与从不戴义齿的对照组年龄和吸烟习惯相匹配。病例的 FEV1 平均比对照组低 140ml，p=0.0013，预计 FEV1 的百分比降低 4%，p=0.0022。应用 GOLD 标准表明，61 例（17.3%）病例存在中重度气流受限，而对照组为 33 例（9.3%），p=0.0051。完全调整的多变量分析显示，戴义齿的部分缺牙男性发生中重度气流减少的可能性显著增加（p=0.01），调整后的优势比（OR）为 2.37（95%置信区间 1.23-4.55）。在研究的 153 名无牙男性中，记录到 44 名（28.4%）中重度气流受限，明显高于部分缺牙戴义齿者（p=0.017）和从不戴义齿者（p<0.0001）。
在研究的中年西欧男性队列中，戴义齿与中重度气流受限的风险增加有关。
