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一例多发性自消退、混合表现的巨大先天性青少年黄色肉芽肿病例。

A Case of Multiple Self-Involuting, Mixed Presentation, Giant Congenital Juvenile Xanthogranuloma.

作者信息

Malana Erika, Kowalski Paul, Gallagher Michelle

机构信息

Pediatric Dermatology, Michigan State University College of Osteopathic Medicine, East Lansing, USA.

Pathology, Michigan Pathology Specialists PC - Spectrum Health, Grand Rapids, USA.

出版信息

Cureus. 2023 Apr 16;15(4):e37644. doi: 10.7759/cureus.37644. eCollection 2023 Apr.

DOI:10.7759/cureus.37644
PMID:37200655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10187945/
Abstract

Juvenile xanthogranuloma (JXG) is an uncommon benign skin disorder of infants and young children characterized by dermal proliferation and infiltration of dendrocytes. We present a unique case of giant congenital JXG with a mixed presentation of macules, papules, nodules, and ulcerations in a neonatal male who was observed until the age of 23 months, by which time all lesions had spontaneously self-involuted. Prior to complete resolution, some lesions took the form of pedunculated protrusions. To our knowledge, this is the first of this atypical case to be presented in the literature.

摘要

幼年性黄色肉芽肿（JXG）是一种罕见的婴幼儿良性皮肤疾病，其特征为真皮层树突状细胞的增殖和浸润。我们报告了一例独特的巨大先天性JXG病例，该病例为一名新生儿男性，表现为斑疹、丘疹、结节和溃疡混合出现，对其进行观察直至23个月龄，此时所有皮损均已自发消退。在完全消退之前，一些皮损呈现为带蒂的突出物。据我们所知，这是文献中首次报道的这种非典型病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd3/10187945/b1f9e8aa4951/cureus-0015-00000037644-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd3/10187945/e857c5633fdc/cureus-0015-00000037644-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd3/10187945/0171082d9018/cureus-0015-00000037644-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd3/10187945/8af40ec8c34c/cureus-0015-00000037644-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd3/10187945/6797b7f77270/cureus-0015-00000037644-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd3/10187945/525dea5b1707/cureus-0015-00000037644-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd3/10187945/b1f9e8aa4951/cureus-0015-00000037644-i06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd3/10187945/e857c5633fdc/cureus-0015-00000037644-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd3/10187945/0171082d9018/cureus-0015-00000037644-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd3/10187945/8af40ec8c34c/cureus-0015-00000037644-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd3/10187945/6797b7f77270/cureus-0015-00000037644-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd3/10187945/525dea5b1707/cureus-0015-00000037644-i05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fd3/10187945/b1f9e8aa4951/cureus-0015-00000037644-i06.jpg

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本文引用的文献

1
Juvenile xanthogranuloma: retrospective analysis of 44 pediatric cases (single tertiary care center experience).幼年黄色肉芽肿：44 例儿科病例的回顾性分析（单中心三级医疗经验）。
Int J Dermatol. 2021 May;60(5):564-569. doi: 10.1111/ijd.15223. Epub 2020 Dec 10.
2
Giant Juvenile Xanthogranuloma: Case Report, Literature Review, and Algorithm for Classification.巨细胞幼年黄色肉芽肿：病例报告、文献回顾及分类算法。
J Cutan Med Surg. 2018 Sep/Oct;22(5):488-494. doi: 10.1177/1203475418777734. Epub 2018 May 21.
3
Risk of intraocular and other extracutaneous involvement in patients with cutaneous juvenile xanthogranuloma.
皮肤幼年性黄色肉芽肿患者眼内及其他皮肤外受累的风险
Pediatr Dermatol. 2018 May;35(3):329-335. doi: 10.1111/pde.13437. Epub 2018 Feb 28.
4
Structural correlations between dermoscopic and histopathological features of juvenile xanthogranuloma.幼年黄色肉芽肿的组织病理与皮肤镜下特征的结构相关性。
J Eur Acad Dermatol Venereol. 2011 Mar;25(3):259-63. doi: 10.1111/j.1468-3083.2010.03819.x.
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Fetal and neonatal histiocytoses.胎儿及新生儿组织细胞增多症
Pediatr Blood Cancer. 2006 Aug;47(2):123-9. doi: 10.1002/pbc.20725.
6
Juvenile xanthogranuloma in childhood and adolescence: a clinicopathologic study of 129 patients from the kiel pediatric tumor registry.儿童和青少年期幼年性黄色肉芽肿：来自基尔儿科肿瘤登记处129例患者的临床病理研究
Am J Surg Pathol. 2005 Jan;29(1):21-8. doi: 10.1097/01.pas.0000147395.01229.06.
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Uncommon histiocytic disorders: the non-Langerhans cell histiocytoses.罕见组织细胞疾病：非朗格汉斯细胞组织细胞增多症
Pediatr Blood Cancer. 2005 Sep;45(3):256-64. doi: 10.1002/pbc.20246.