Bashir Anam, Tejada Andrea Gosalvez, Oldham Keith T, Thakrar Pooja D, Lerner Diana G
From the Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI.
Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI.
JPGN Rep. 2023 Apr 18;4(2):e310. doi: 10.1097/PG9.0000000000000310. eCollection 2023 May.
Protein-losing enteropathy (PLE) is caused by protein loss through the gastrointestinal tract which results in hypoalbuminemia. The most common causes of PLE in children include cow milk protein allergy, celiac disease, inflammatory bowel disease, hypertrophic gastritis, intestinal lymphangiectasia, and right-sided heart dysfunction. We present a case of a 12-year-old male with bilateral lower extremity edema, hypoalbuminemia, elevated stool alpha-1-antitrypsin, and microcytic anemia. He was found to have a trichobezoar in the stomach extending to the jejunum, an unusual cause of PLE. The patient underwent an open laparotomy and gastrostomy to remove the bezoar. Follow-up confirmed resolution of hypoalbuminemia.
蛋白丢失性肠病（PLE）是由蛋白质通过胃肠道丢失引起的，这会导致低白蛋白血症。儿童PLE最常见的病因包括牛奶蛋白过敏、乳糜泻、炎症性肠病、肥厚性胃炎、肠淋巴管扩张症和右心功能不全。我们报告一例12岁男性患者，有双侧下肢水肿、低白蛋白血症、粪便α-1抗胰蛋白酶升高和小细胞贫血。他被发现胃内有一个毛粪石延伸至空肠，这是PLE的一个不寻常病因。患者接受了剖腹探查术和胃造口术以取出粪石。随访证实低白蛋白血症已得到缓解。
