Tuna Bilge, Tuna Volkan
Department of Otorhinolaryngology, Bursa City Hospital, 16110 Bursa, Turkey.
Department of Obstetrics and Gynecology, Bursa Yüksek İhtisas Training and Research Hospital, Bursa, Turkey.
Indian J Otolaryngol Head Neck Surg. 2023 Apr;75(Suppl 1):1072-1077. doi: 10.1007/s12070-023-03612-9. Epub 2023 Mar 2.
We aimed to investigate the effects of female gender hormones on post-COVID parosmia in females. Twenty-three female patients aged 18-45 who had COVID-19 disease in the last 12 months were included in the study. Estradiol (E2), prolactin (PRL), luteotrophic hormone (LH), follicular stimulating hormone (FSH), and thyroid stimulating hormone (TSH) values were measured in the blood of all participants and a parosmia questionnaire was applied for the subjective evaluation of olfactory function. Values between 4 and 16 were obtained as parosmia score (PS), and the lowest PS showed the most severe complaint. The mean age of the patients was 31 (18-45). According to the PS, patients with a score of 10 or less were classified as Group 1, and patients above 10 were considered Group 2. The age difference between Groups 1 and 2 was statistically significant and younger patients were found to have more complaints of parosmia (25 and 34, respectively, p-value 0.014). It was found that patients with severe parosmia had lower E2 values and there was a statistically significant difference (p-value 0.042) between groups 1 and 2 in terms of E2 values (34 ng/L and 59 ng/L, respectively). There was no significant difference between the two groups in terms of PRL, LH, FSH, TSH levels, or FSH/LH ratio. It may be recommended to measure E2 values in female patients whose parosmia continues after COVID-19 infection.
The online version contains supplementary material available at 10.1007/s12070-023-03612-9.
我们旨在研究女性性别激素对女性新冠后嗅觉异常的影响。本研究纳入了23名年龄在18 - 45岁之间、在过去12个月内感染过新冠病毒的女性患者。测量了所有参与者血液中的雌二醇（E2）、催乳素（PRL）、促黄体生成素（LH）、促卵泡生成素（FSH）和促甲状腺激素（TSH）值，并应用嗅觉异常问卷对嗅觉功能进行主观评估。嗅觉异常评分（PS）在4至16之间，最低的PS表示最严重的症状。患者的平均年龄为31岁（18 - 45岁）。根据PS，评分10分及以下的患者被归为第1组，评分高于10分的患者被视为第2组。第1组和第2组之间的年龄差异具有统计学意义，且发现年轻患者嗅觉异常的症状更多（分别为25例和34例，p值为0.014）。发现嗅觉异常严重的患者E2值较低，且第1组和第2组在E2值方面存在统计学显著差异（p值为0.042）（分别为34 ng/L和59 ng/L）。两组在PRL、LH、FSH、TSH水平或FSH/LH比值方面无显著差异。对于新冠病毒感染后嗅觉异常持续的女性患者，建议测量其E2值。
在线版本包含可在10.1007/s12070 - 023 - 03612 - 9获取的补充材料。
