Falahi Sara, Feizolahi Parisa, Monshizadeh Ali, Mahmoudi Zahra, Mahdavi Jila, Salari Farhad, Karaji Ali Gorgin, Rezaiemanesh Alireza
Department of Immunology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Pathology, Legal Medicine Organization, Kermanshah, Iran.
Ther Adv Allergy Rhinol. 2023 May 8;14:27534030231170874. doi: 10.1177/27534030231170874. eCollection 2023 Jan-Dec.
Allergic rhinitis (AR) is the most common inflammatory disorder of the upper airway caused by aberrant immune responses to allergens in genetically predisposed individuals. Recently, the long noncoding RNA (lncRNA) antisense noncoding RNA in the INK4 locus (ANRIL) has been identified as a novel genetic factor associated with increased AR risk.
This study aimed to evaluate the potential correlation of gene single nucleotide polymorphisms (SNPs) with AR risk in the Kurdish population of Kermanshah, Iran.
In this case-control study, 130 AR patients and 130 healthy controls were recruited to genotype for two SNPs of the gene (rs1333048 and rs10757278) using the Tetra-primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR) method.
Our results showed no significant difference for the alleles and genotypes frequency distribution of lncRNA ANRIL SNPs (rs1333048 and rs10757278) between AR patients and healthy controls ( > 0.05). Additionally, the dominant, additive and recessive genetic models of both SNPs were not associated with altered susceptibility to AR risk ( > 0.05).
The results demonstrated that the gene rs1333048 and rs10757278 polymorphisms might not be associated with susceptibility to AR in the Kurdish population of Kermanshah, Iran.
变应性鼻炎（AR）是上气道最常见的炎症性疾病，由遗传易感性个体对变应原的异常免疫反应引起。最近，INK4基因座中的长链非编码RNA（lncRNA）反义非编码RNA（ANRIL）已被确定为与AR风险增加相关的一种新的遗传因素。
本研究旨在评估伊朗克尔曼沙阿库尔德人群中基因单核苷酸多态性（SNP）与AR风险的潜在相关性。
在这项病例对照研究中，招募了130例AR患者和130名健康对照，采用四引物扩增阻滞突变系统聚合酶链反应（T-ARMS-PCR）方法对该基因的两个SNP（rs1333048和rs10757278）进行基因分型。
我们的结果显示，AR患者和健康对照之间lncRNA ANRIL SNPs（rs1333048和rs10757278）的等位基因和基因型频率分布无显著差异（P>0.05）。此外，两个SNP的显性、加性和隐性遗传模型均与AR风险易感性改变无关（P>0.05）。
结果表明，在伊朗克尔曼沙阿的库尔德人群中，该基因的rs1333048和rs10757278多态性可能与AR易感性无关。
