增强脉络丛 NKCC1：从 CSF 清除到出血后脑积水的潜在治疗方法。
Boosting NKCC1 in the choroid plexus: From CSF clearance to a potential therapy for posthemorrhagic hydrocephalus.
机构信息
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Erling Skjalgsons Gate 1, 7491 Trondheim, Norway.
Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Erling Skjalgsons Gate 1, 7491 Trondheim, Norway.
出版信息
Neuron. 2023 May 17;111(10):1521-1523. doi: 10.1016/j.neuron.2023.04.014.
In this issue of Neuron, Sadegh et al. identify a novel potential therapeutical target for posthemorrhagic hydrocephalus (PHH). The authors identified that overexpression of Na-K-2Cl cotransporter-1 (NKCC1) in the choroid plexus relieves ventriculomegaly and enhances cerebrospinal fluid (CSF) clearance in improved PHH mouse models.
本期《神经元》杂志，Sadegh 等人发现了一种治疗脑出血后脑积水（PHH）的新潜在治疗靶点。作者发现，脉络丛中钠-钾-2 氯协同转运蛋白-1（NKCC1）的过度表达可减轻脑室扩大，并增强 PHH 小鼠模型中的脑脊液（CSF）清除率。
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