Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, 11420, Indonesia.
Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, 11420, Indonesia.
Clin Nutr ESPEN. 2023 Jun;55:38-43. doi: 10.1016/j.clnesp.2023.02.005. Epub 2023 Feb 11.
BACKGROUND & AIM: Long-term consumption of trans-fat has been linked with its incorporation in brain neural membrane that could lead into alteration of signalling pathways, including Brain Derived Neurotrophic Factor (BDNF). As an ubiquitous neurotrophin, BDNF is believed to play a role in the regulation of blood pressure yet prior studies shown conflicting results to its effect. Moreover, direct effect of trans fat intake to hypertension has not yet been elucidated. This study aimed to investigate the role of BDNF and its association between trans-fat intake and hypertension.
MATERIALS & METHODS: We conducted a population study in Natuna Regency which once reportedly has the highest prevalence of hypertension from Indonesian National Health Survey. Subjects with hypertension and those without hypertension were recruited for the study. Demographic data, physical examination, and food recall were collected. The level of BDNF from all subjects were obtained through analysis of blood samples.
A total of 181 participants were included in this study, comprising 134 (74%) hypertensive subjects and 47 (26%) normotensive subjects. Median of daily trans-fat intake of hypertensive subjects was higher compared to normotensive subjects (0,013 [0,0003-0,07] vs 0,010 [0,0006-0,06] % of total energy/day, p = 0,021). Interaction analysis showed significant results for plasma BDNF level in relationship of trans-fat intake and hypertension (p = 0,011). Trans-fat intake association to hypertension in overall subjects showed odds ratio (OR) of 1,85 95%CI 1,05-3,26 (p = 0,034), while in those with low-middle tercile BDNF level the OR was 3,35 95%CI 1,46-7,68 (p = 0,004).
Plasma BDNF level has a modifying effect in the association between trans-fat intake and hypertension. Subjects with high trans-fat intake, while having low BDNF level, have the highest probability for hypertension.
长期摄入反式脂肪已被证明与脑神经网络中的反式脂肪结合有关，这可能导致信号通路的改变，包括脑源性神经营养因子（BDNF）。作为一种普遍存在的神经营养因子，BDNF 被认为在调节血压方面发挥作用，但先前的研究结果显示其作用存在矛盾。此外，反式脂肪摄入直接导致高血压的作用尚未阐明。本研究旨在探讨 BDNF 的作用及其与反式脂肪摄入和高血压之间的关系。
我们在纳土纳县进行了一项人群研究，该县曾被报道是印度尼西亚国家健康调查中高血压患病率最高的地区。研究招募了高血压患者和非高血压患者。收集了人口统计学数据、体格检查和食物回忆。通过分析所有受试者的血液样本获得 BDNF 水平。
本研究共纳入 181 名参与者，包括 134 名（74%）高血压患者和 47 名（26%）血压正常患者。高血压患者的每日反式脂肪摄入量中位数高于血压正常患者（0，013 [0，0003-0，07] 与 0，010 [0，0006-0，06] %的总能量/天，p = 0.021）。交互分析显示，血浆 BDNF 水平与反式脂肪摄入和高血压之间存在显著关系（p = 0.011）。总体人群中，反式脂肪摄入与高血压的关联的比值比（OR）为 1.85（95%CI 1.05-3.26）（p = 0.034），而在 BDNF 水平处于低-中三分位数的人群中，OR 为 3.35（95%CI 1.46-7.68）（p = 0.004）。
血浆 BDNF 水平在反式脂肪摄入与高血压之间的关联中具有调节作用。反式脂肪摄入高且 BDNF 水平低的受试者患高血压的概率最高。
