Students' Scientific Research Center, Isfahan University of Medical Sciences, Isfahan, Iran; Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Clin Nutr. 2024 Jun;43(6):1353-1362. doi: 10.1016/j.clnu.2024.04.031. Epub 2024 Apr 22.
There is a lack of evidence on dietary intake of methyl donor nutrients with metabolic health status and related biomarkers. Thus, this study aimed to assess the relation between methyl donor nutrients intake and metabolic health status with regarding the interactive roles of brain-derived neurotrophic factor (BDNF) and adropin in Iranian adults.
This cross-sectional survey was conducted among 527 Iranian adults (45.7% female) selected by multistage cluster random-sampling method. A validated food frequency questionnaire was used to evaluate participants' dietary intake. Metabolic unhealthy status was defined by Wildman criteria as having ≥ 2 of hyperglycemia, hypertriglyceridemia, hypo-HDL-cholesterolemia, hypertension, chronic inflammation, and insulin resistance. Concentrations of metabolic parameters, BDNF and adropin were determined using fasting blood samples.
An inverse association was found between methyl donor nutrients intake and metabolically unhealthy status in multivariable-adjusted model (OR = 0.30; 95%CI: 0.12-0.75). This association was especially significant among overweight/obese adults and was stronger in women. Additionally, consumption of vitamin B6 and choline was separately related to reduced odds of metabolically unhealthy status. Methyl donor intake was not significantly related to low BDNF (OR = 0.93; 95%CI: 0.60-1.44) and adropin (OR = 0.71; 95%CI: 0.44-1.15). However, the interaction between high methyl donor nutrients intake and high BDNF was related to lower odds of metabolically unhealthy status in multivariable-adjusted model (OR = 0.27; 95%CI: 0.11-0.67).
Higher intake of methyl donor nutrients, alone and in interaction with BDNF levels, was associated with decreased odds of metabolically unhealthy status in Iranian adults.
目前缺乏关于与代谢健康状况和相关生物标志物相关的甲基供体营养素的饮食摄入量的证据。因此，本研究旨在评估伊朗成年人中甲基供体营养素的摄入量与代谢健康状况之间的关系，并考虑脑源性神经营养因子（BDNF）和瘦素的相互作用。
本横断面研究采用多阶段聚类随机抽样方法从 527 名伊朗成年人（45.7%为女性）中进行。使用经过验证的食物频率问卷评估参与者的饮食摄入量。代谢不健康状态根据 Wildman 标准定义为存在≥2 项高血糖、高三酰甘油血症、低高密度脂蛋白胆固醇血症、高血压、慢性炎症和胰岛素抵抗。使用空腹血样测定代谢参数、BDNF 和瘦素的浓度。
在多变量调整模型中，甲基供体营养素的摄入量与代谢不健康状态呈负相关（OR=0.30；95%CI：0.12-0.75）。在超重/肥胖成年人中，这种相关性更为显著，并且在女性中更强。此外，维生素 B6 和胆碱的摄入量与代谢不健康状态的几率降低有关。甲基供体的摄入量与低 BDNF（OR=0.93；95%CI：0.60-1.44）和瘦素（OR=0.71；95%CI：0.44-1.15）无显著相关性。然而，高甲基供体营养素摄入与高 BDNF 之间的相互作用与多变量调整模型中代谢不健康状态的几率降低有关（OR=0.27；95%CI：0.11-0.67）。
较高的甲基供体营养素摄入，单独或与 BDNF 水平相互作用，与伊朗成年人代谢不健康状态的几率降低有关。
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