Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Clin Nutr ESPEN. 2023 Jun;55:97-102. doi: 10.1016/j.clnesp.2023.03.004. Epub 2023 Mar 10.
BACKGROUND & AIMS: Dietary acid load causes metabolic acidosis, which leads to inflammation and cell change, both of which are related to cancer development. Even though a high acid load has been associated with an increased risk of breast cancer (BC), epidemiologic evidence correlating diet-dependent acid load and cancer risk, particularly for BC, is still lacking. As a result, we intend to investigate its potential role.
The potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores were calculated in this case-control study using the dietary intake of individuals as determined by a verified FFQ. Logistic regression was used to calculate odds ratios (ORs), which were adjusted for probable confounders.
Using multivariate logistic regression models, the odds ratios (OR) of BC according to quartiles of PRAL and NEAP scores revealed that neither PRAL (P-trend = 0.53) nor NEAP (P-trend = 0.19) scores were significantly associated with BC risk. Multiple logistic regressions remained non-significant after controlling for covariates, indicating no significant relationships between PRAL (P-trend = 0.96) and NEAP (trend = 0.45) scores and the odds of BC.
According to the findings of our study, there is no relation between DAL and the risk of BC in Iranian women.
饮食酸负荷会导致代谢性酸中毒，进而引发炎症和细胞变化，而这两者都与癌症的发生有关。尽管高酸负荷与乳腺癌（BC）风险增加有关，但仍缺乏与饮食相关的酸负荷和癌症风险相关的流行病学证据，特别是与 BC 相关的证据。因此，我们旨在研究其潜在作用。
本病例对照研究使用个体饮食摄入的经过验证的 FFQ 计算了潜在肾酸负荷（PRAL）和净内源性酸产生（NEAP）评分。使用逻辑回归计算了比值比（OR），并针对可能的混杂因素进行了调整。
使用多变量逻辑回归模型，根据 PRAL 和 NEAP 评分四分位数的 BC 比值比（OR）表明，PRAL（P 趋势=0.53）和 NEAP（P 趋势=0.19）评分均与 BC 风险无显著相关性。在控制了协变量后，多元逻辑回归仍然不显著，表明 PRAL（P 趋势=0.96）和 NEAP（趋势=0.45）评分与 BC 发生的几率之间没有显著关系。
根据我们的研究结果，伊朗女性的 DAL 与 BC 风险之间没有关系。
