Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, Birjand, Iran.
Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Cardiovasc Hematol Agents Med Chem. 2024;22(2):151-158. doi: 10.2174/1871525721666230518101627.
Sepsis is a significant cause of mortality worldwide. This study aimed to compare clinical and laboratory characteristics of sepsis in patients addicted to illicit drugs versus patients with no illicit drug addiction.
In this cross-sectional study, all patients hospitalized with sepsis diagnosis were recruited within six months from September to March 2019. Sixty patients for each group (illicit drugaddicted and non-addicted individuals) were selected. The data relating to illicit drug consumption, serum indices, the current focus of infection, duration of hospitalization, and disease outcomes were collected. Patients who had an illicit drug addiction were compared with non-addicted patients in terms of clinical and laboratory parameters. The data collected were analyzed using SPSS software (version 19).
The bacterial load in the urine culture was statistically significant in both groups and higher in the non-addicted group. The frequency distributions of focus of infection, duration of hospitalization, and outcome were not significantly different between the two groups. The serum sodium and total neutrophils were significantly higher in the addicted group. However, the MCHC level was significantly lower (p < 0.05).
Opium may have stimulated the immune system and reduced bacterial infection in septic patient users.
脓毒症是全球范围内导致死亡的一个重要原因。本研究旨在比较有吸毒史和无吸毒史的脓毒症患者的临床和实验室特征。
在这项横断面研究中，于 2019 年 9 月至 3 月期间的六个月内，招募了所有因脓毒症住院的患者。每组（吸毒者和非吸毒者）各选取 60 名患者。收集了与吸毒、血清指标、当前感染焦点、住院时间和疾病结局相关的数据。将有吸毒史的患者与无吸毒史的患者进行了临床和实验室参数的比较。使用 SPSS 软件（版本 19）对收集的数据进行分析。
两组患者的尿液培养细菌负荷均有统计学意义，且非吸毒组更高。两组患者的感染焦点、住院时间和结局的频率分布无显著差异。吸毒组的血清钠和总中性粒细胞明显升高，而 MCHC 水平明显降低（p<0.05）。
阿片类物质可能刺激了脓毒症患者的免疫系统，减少了细菌感染。
