Knutsen O H
Crit Care Med. 1986 Jul;14(7):638-41. doi: 10.1097/00003246-198607000-00011.
The stability of the fat emulsion Intralipid 20% depends to a great extent on the electric-repulsive forces between the fat particles. The negative charge of the fat particles (zeta-potential) in Intralipid 20% was measured in large bags containing three different commercially available amino acid solutions, two of which had electrolytes. In each case, the electronegativity was not great enough to give the solution adequate stability. When arginine and methionine were added to Intralipid, an increase in pH resulted in more of an electronegative zeta-potential. Varying the concentration of arginine did not affect the zeta-potential the same as changing the pH of the mixture. Thus, a high pH and, to a lesser extent, the quantities of amino acids appear to be important factors in increasing the electrostability of Intralipid.
20%英脱利匹特脂肪乳剂的稳定性在很大程度上取决于脂肪颗粒之间的电排斥力。在装有三种不同市售氨基酸溶液的大袋子中测量了20%英脱利匹特中脂肪颗粒的负电荷（ζ电位），其中两种含有电解质。在每种情况下，电负性都不足以使溶液具有足够的稳定性。当向英脱利匹特中添加精氨酸和蛋氨酸时，pH值升高会导致ζ电位的电负性增加。改变精氨酸的浓度对ζ电位的影响与改变混合物的pH值不同。因此，高pH值以及在较小程度上氨基酸的量似乎是增加英脱利匹特电稳定性的重要因素。
