• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

同时输注三种药物时，中心静脉营养输注、静脉用脂肪乳剂和治疗药物对脂肪乳剂粒径的影响。

Effect of Central Venous Nutrition Infusion, Intravenous Fat Emulsion, and Therapeutic Agents on the Particle Size of Fat Emulsion for Simultaneous Administration of Three Drugs.

机构信息

Faculty of Pharmacy, Osaka Ohtani University, Tondabayashi, Japan.

Department of Pharmacy, Higashi-Sumiyoshi Morimoto Hospital, Osaka, Japan.

出版信息

Ann Nutr Metab. 2022;78(6):307-315. doi: 10.1159/000526329. Epub 2022 Aug 5.

DOI:10.1159/000526329
PMID:35933978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9808686/
Abstract

BACKGROUND

In Japan, therapeutic agents are often administered through the side tube of a central venous line or mixed with a total parenteral nutrition (TPN) infusion. This is expected to result in the mixture of three drugs in the infusion line: the infusion product for TPN, the fat emulsion, and the therapeutic agent. Therefore, we investigated whether various therapeutic agents affect the particle size of the fat emulsion.

METHODS

In model of administration A, the TPN infusion formulation was administered through the main tube, and the fat emulsion and therapeutic agents were simultaneously administered through the side tube; 21 therapeutic agents were used. In model of administration B, the TPN infusion formulation mixed with therapeutic agents was administered through the main tube, and the fat emulsion was simultaneously administered through the side tube; 20 therapeutic agents were used. The number of fine particles for each particle size range in the mixed solution was measured over time using a light-shielding automatic fine-particle measuring device.

RESULTS

In model A, the number of fine particles in the fat emulsion changed rapidly for five therapeutic agents and slowly for two therapeutic agents. In model B, this change occurred drastically for five therapeutic agents and slowly for one therapeutic agent.

CONCLUSIONS

Some therapeutic agents may contribute to fat particle aggregation. Therefore, these therapeutic agents should not be concurrently administered with fat emulsions.

摘要

背景

在日本，治疗药物通常通过中心静脉导管的侧管给药，或与全胃肠外营养（TPN）输注混合。这预计会导致输注管路中三种药物的混合：TPN 输注产品、脂肪乳剂和治疗药物。因此，我们研究了各种治疗药物是否会影响脂肪乳剂的粒径。

方法

在给药模型 A 中，通过主管给予 TPN 输注制剂，同时通过侧管给予脂肪乳剂和治疗药物；使用了 21 种治疗药物。在给药模型 B 中，通过主管给予混合有治疗药物的 TPN 输注制剂，同时通过侧管给予脂肪乳剂；使用了 20 种治疗药物。使用遮光自动微粒子测量装置，随着时间的推移，测量混合溶液中每个粒径范围内的微粒子数量。

结果

在模型 A 中，五种治疗药物的脂肪乳剂中的微粒子数量迅速变化，两种治疗药物的微粒子数量缓慢变化。在模型 B 中，五种治疗药物的变化急剧，一种治疗药物的变化缓慢。

结论

一些治疗药物可能会导致脂肪颗粒聚集。因此，这些治疗药物不应与脂肪乳剂同时给药。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9352/9808686/0ba4d1edd933/anm-0078-0307-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9352/9808686/d2d8e8a2d880/anm-0078-0307-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9352/9808686/18b4862832f6/anm-0078-0307-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9352/9808686/0ba4d1edd933/anm-0078-0307-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9352/9808686/d2d8e8a2d880/anm-0078-0307-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9352/9808686/18b4862832f6/anm-0078-0307-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9352/9808686/0ba4d1edd933/anm-0078-0307-g03.jpg

相似文献

1
Effect of Central Venous Nutrition Infusion, Intravenous Fat Emulsion, and Therapeutic Agents on the Particle Size of Fat Emulsion for Simultaneous Administration of Three Drugs.同时输注三种药物时，中心静脉营养输注、静脉用脂肪乳剂和治疗药物对脂肪乳剂粒径的影响。
Ann Nutr Metab. 2022;78(6):307-315. doi: 10.1159/000526329. Epub 2022 Aug 5.
2
Compatibility of Intravenous Fat Emulsion with Antibiotics for Secondary Piggyback Infusion.静脉脂肪乳与抗生素在二次背驮式输注中的相容性。
Ann Nutr Metab. 2018;73(3):227-233. doi: 10.1159/000492940. Epub 2018 Sep 13.
3
Microbial growth and importance of flushing inside closed-type infusion devices during administration of lipid emulsion setting.输液器在输注脂肪乳剂时的密闭状态下，微生物的生长情况和冲洗的重要性。
Int J Med Sci. 2021 Jun 26;18(14):3106-3111. doi: 10.7150/ijms.60200. eCollection 2021.
4
Options available for the infusion of lipid emulsion in home parenteral nutrition (HPN): a questionnaire survey for hospitals in Japan where HPN is practiced.家庭肠外营养（HPN）中脂肪乳剂输注的可用选项：针对日本开展HPN的医院的问卷调查
Nutrition. 2006 Apr;22(4):361-6. doi: 10.1016/j.nut.2005.07.018. Epub 2006 Feb 3.
5
Effect of the continuous administration of fat emulsion on the infiltration of intravenous lines in infants receiving peripheral parenteral nutrition solutions.持续输注脂肪乳剂对接受外周肠外营养溶液的婴儿静脉管路浸润的影响。
JPEN J Parenter Enteral Nutr. 1989 Nov-Dec;13(6):628-32. doi: 10.1177/0148607189013006628.
6
How to perform appropriate flushing after lipid emulsion administration using totally implantable venous access devices in long-term total parenteral nutrition and home parenteral nutrition.如何在长期全肠外营养和家庭肠外营养中使用完全植入式静脉通路装置进行适当的脂肪乳剂输注后冲洗。
Clin Nutr ESPEN. 2021 Feb;41:287-292. doi: 10.1016/j.clnesp.2020.11.019. Epub 2020 Dec 18.
7
[Postoperative total parenteral nutrition with fat emulsion for patients with esophageal varices].[食管静脉曲张患者术后应用脂肪乳剂的全胃肠外营养]
Nihon Geka Gakkai Zasshi. 1988 Mar;89(3):325-35.
8
Effect of Lipid Emulsion on Stability of Ampicillin in Total Parenteral Nutrition.脂肪乳对全胃肠外营养中氨苄西林稳定性的影响。
Nutrients. 2019 Mar 6;11(3):559. doi: 10.3390/nu11030559.
9
Physical compatibility of total parenteral nutrition and drugs in Y-site administration to children from neonates to adolescents.新生儿至青少年儿童经Y型接口肠外营养与药物的物理相容性
J Pharm Pharmacol. 2017 Apr;69(4):448-462. doi: 10.1111/jphp.12647. Epub 2016 Oct 7.
10
Preparation of fine emulsified fat particles without glycerol for intravenous nutrition.用于静脉营养的无甘油精细乳化脂肪颗粒的制备
Eur J Pharm Sci. 1999 Oct;9(1):67-73. doi: 10.1016/s0928-0987(99)00045-7.

本文引用的文献

1
Compatibility of Intravenous Fat Emulsion with Antibiotics for Secondary Piggyback Infusion.静脉脂肪乳与抗生素在二次背驮式输注中的相容性。
Ann Nutr Metab. 2018;73(3):227-233. doi: 10.1159/000492940. Epub 2018 Sep 13.
2
Compatibility of medications with 3-in-1 parenteral nutrition admixtures.药物与三合一肠外营养混合液的相容性。
JPEN J Parenter Enteral Nutr. 1999 Mar-Apr;23(2):67-74. doi: 10.1177/014860719902300267.
3
The influence of electrolytes on fat emulsions stability in total parenteral nutrition mixtures.电解质对全胃肠外营养混合液中脂肪乳剂稳定性的影响。
Acta Pol Pharm. 1995 Jan-Feb;52(1):17-20.
4
FDA safety alert: hazards of precipitation associated with parenteral nutrition.美国食品药品监督管理局安全警报：肠外营养相关的沉淀风险
Nutr Clin Pract. 1996 Apr;11(2):59-65. doi: 10.1177/011542659601100259.
5
Elimination rate of fat emulsion particles from plasma in Japanese subjects as determined by a triglyceride clamp technique.通过甘油三酯钳夹技术测定日本受试者血浆中脂肪乳剂颗粒的清除率。
Nutrition. 1996 Feb;12(2):79-82. doi: 10.1016/0899-9007(96)90703-0.
6
A study of intravenous emulsion compatibility: effects of dextrose, amino acids, and selected electrolytes.静脉乳液相容性研究：葡萄糖、氨基酸和特定电解质的影响。
Drug Intell Clin Pharm. 1981 Mar;15(3):184-93. doi: 10.1177/106002808101500304.
7
Stability of intralipid fat emulsion in amino acid solutions.脂肪乳剂在氨基酸溶液中的稳定性。
Crit Care Med. 1986 Jul;14(7):638-41. doi: 10.1097/00003246-198607000-00011.
8
Capacity of high-density lipoprotein for donating apolipoproteins to fat particles in hypertriglyceridemia induced by fat infusion.脂肪输注诱导的高甘油三酯血症中高密度脂蛋白向脂肪颗粒捐赠载脂蛋白的能力。
Nutrition. 1991 Sep-Oct;7(5):355-7.
9
Hazards of parenteral treatment: do particles count?肠胃外治疗的风险：微粒重要吗？
Arch Dis Child. 1992 Dec;67(12):1475-7. doi: 10.1136/adc.67.12.1475.