全身给药后兔眼前房中荧光素和羧基荧光素的光谱位移。
Spectral shift of fluorescein and carboxyfluorescein in the anterior chamber of the rabbit eye following systemic administration.
作者信息
Neault T R, McLaren J W, Brubaker J H, Brubaker R F
出版信息
Curr Eye Res. 1986 May;5(5):337-41. doi: 10.3109/02713688609025171.
PMID:3720340
Abstract
Systemically administered fluorescein is converted to fluorescein glucuronide. The conjugate is fluorescent and interferes with the measurement of fluorescein in the anterior chamber. Carboxyfluorescein is a hydrophilic derivative of fluorescein. In the rabbit, carboxyfluorescein is not converted as readily to a fluorescent metabolite. Thus, carboxyfluorescein has potential advantages as a quantitative fluorophore for studies of aqueous humor dynamics.
摘要
全身给药的荧光素会转化为荧光素葡糖醛酸苷。该共轭物具有荧光性，会干扰前房内荧光素的测量。羧基荧光素是荧光素的一种亲水性衍生物。在兔子体内，羧基荧光素不容易转化为荧光代谢物。因此，羧基荧光素作为研究房水动力学的定量荧光团具有潜在优势。
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