在时间隔离（自由运行）状态下睡眠期间，人体生长激素的释放会减少。

Human growth hormone release is decreased during sleep in temporal isolation (free-running).

作者信息

Moline M L, Monk T H, Wagner D R, Pollak C P, Kream J, Fookson J E, Weitzman E D, Czeisler C A

出版信息

Chronobiologia. 1986 Jan-Mar;13(1):13-9.

PMID:3720426

Abstract

Growth hormone (hGH) secretion was measured during sleep in 10 healthy male subjects isolated from all time cues. HGH concentrations following sleep onset were compared between scheduled sleep episodes (entrainment) and self-selected sleep episodes (free-running). Peak sleep-related hGH values were decreased significantly during free-running. The duration of the first slow wave sleep (SWS) episode and the latency to the first REM sleep episode also decreased significantly during free-running. The latencies from sleep onset to SWS and to peak hGH secretion did not differ between entrainment and free-running. These results suggest that sleep-related hGH secretion begins 'on time' during free-running, but is terminated earlier. Thus, while sleep onset facilitates hGH release, the timing of other stages of sleep such as REM may alter the magnitude of sleep-related hGH secretion.

摘要

在与所有时间线索隔绝的10名健康男性受试者睡眠期间测量了生长激素（hGH）分泌情况。比较了定时睡眠时段（同步化）和自主选择睡眠时段（自由运行）入睡后的hGH浓度。自由运行期间，与睡眠相关的hGH峰值显著降低。自由运行期间，首个慢波睡眠（SWS）时段的时长以及首个快速眼动睡眠（REM）时段的潜伏期也显著缩短。同步化和自由运行期间，从入睡到SWS以及到hGH分泌峰值的潜伏期并无差异。这些结果表明，在自由运行期间，与睡眠相关的hGH分泌按时开始，但更早终止。因此，虽然入睡促进hGH释放，但睡眠其他阶段（如REM）的时间安排可能会改变与睡眠相关的hGH分泌量。