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SEOM-GETNE 临床指南：用于胃肠胰和支气管神经内分泌肿瘤（NENs）的诊断和治疗（2022 年）。

SEOM-GETNE clinical guidelines for the diagnosis and treatment of gastroenteropancreatic and bronchial neuroendocrine neoplasms (NENs) (2022).

机构信息

Servicio de Oncología Médica, Hospital Universitario Vall D'Hebron, Ps Vall d'Hebron, 119-129, 08035, Barcelona, Spain.

Servicio de Oncología Médica, Hospital Universitario Ramón y Cajal, Madrid, Spain.

出版信息

Clin Transl Oncol. 2023 Sep;25(9):2692-2706. doi: 10.1007/s12094-023-03205-6. Epub 2023 May 19.

DOI:10.1007/s12094-023-03205-6
PMID:37204633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10425298/
Abstract

Neuroendocrine neoplasms (NENs) are a heterogeneous family of tumors of challenging diagnosis and clinical management. Their incidence and prevalence continue to rise mainly due to an improvement on diagnostic techniques and awareness. Earlier detection, along with steadfast improvements in therapy, has led to better prognosis over time for advanced gastrointestinal and pancreatic neuroendocrine tumors. The aim of this guideline is to update evidence-based recommendations for the diagnosis and treatment of gastroenteropancreatic and lung NENs. Diagnostic procedures, histological classification, and therapeutic options, including surgery, liver-directed therapy, peptide receptor radionuclide therapy, and systemic hormonal, cytotoxic or targeted therapy, are reviewed and discussed, and treatment algorithms to guide therapeutic decisions are provided.

摘要

神经内分泌肿瘤（NENs）是一组具有挑战性的诊断和临床管理的异质性肿瘤家族。它们的发病率和患病率持续上升，主要是由于诊断技术和认识的提高。早期检测，以及治疗的稳步改进，导致晚期胃肠胰神经内分泌肿瘤的预后随时间的推移而改善。本指南的目的是更新胃肠胰神经内分泌肿瘤和肺神经内分泌肿瘤的诊断和治疗的循证推荐。对诊断程序、组织学分类和治疗选择，包括手术、肝定向治疗、肽受体放射性核素治疗以及全身激素、细胞毒性或靶向治疗进行了审查和讨论，并提供了指导治疗决策的治疗算法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8272/10425298/53e0f6b356a7/12094_2023_3205_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8272/10425298/6d26cc45992f/12094_2023_3205_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8272/10425298/e466479510c3/12094_2023_3205_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8272/10425298/4a1a97c38f87/12094_2023_3205_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8272/10425298/53e0f6b356a7/12094_2023_3205_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8272/10425298/6d26cc45992f/12094_2023_3205_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8272/10425298/13d33b5e8d45/12094_2023_3205_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8272/10425298/e466479510c3/12094_2023_3205_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8272/10425298/4a1a97c38f87/12094_2023_3205_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8272/10425298/53e0f6b356a7/12094_2023_3205_Fig5_HTML.jpg

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