一项基于社区的研究，报告了在认知障碍参与者中，报告者和认知正常的参与者之间人口统计学和临床信息的一致性。
A community-based study of reporting demographic and clinical information concordance between informants and cognitively impaired participants.
机构信息
Department of Neurology, University of Michigan Medical School, 1500 E. Medical Center Drive, CVC 3194, Ann Arbor, MI, 48109-5855, USA.
Department of Physical Medicine and Rehabilitation, University of Michigan Medical School, Ann Arbor, MI, USA.
出版信息
Aging Clin Exp Res. 2023 Jul;35(7):1571-1576. doi: 10.1007/s40520-023-02435-6. Epub 2023 May 19.
BACKGROUND
Understanding concordance between informants' and cognitively impaired participants' information reporting is crucial for Alzheimer's and Alzheimer's-related dementia studies.
METHODS
The Brain Attack Surveillance in Corpus Christi-Cognitive is a community-based cohort study. Households in Nueces County, Texas, USA, were randomly identified. 330 dyads of participants and their named informants answered questions. Models were generated to examine which predictors, including age, gender, ethnicity, cognitive function, and relationship to informant, influenced answer discordance.
RESULTS
For demographic items, female participants and participants with spouses/partners as informants had significantly less discordance, with incidence rate rations (IRRs) of 0.65 (CI = 0.44, 0.96) and 0.41 (CI = 0.23, 0.75), respectively. For health items, better cognitive function of the participant was associated with less discordance, with an IRR of 0.85 (CI = 0.76, 0.94).
CONCLUSIONS
Demographic information concordance is most associated with gender and informant-participant relationship. Level of cognitive function is most associated with concordance for health information.
CLINICALTRIALS
gov identifier NCT03403257.
背景
了解信息报告者和认知障碍参与者之间的一致性对于阿尔茨海默病和阿尔茨海默病相关痴呆症的研究至关重要。
方法
脑卒中超群监测-Cognition（Brain Attack Surveillance in Corpus Christi-Cognition， BASIC）是一项基于社区的队列研究。美国得克萨斯州努埃塞斯县的家庭被随机确定。330 对参与者及其指定的信息报告者回答了问题。生成模型以检查哪些预测因素（包括年龄、性别、种族、认知功能和与信息报告者的关系）会影响答案的不一致性。
结果
在人口统计学项目中，女性参与者和配偶/伴侣作为信息报告者的参与者的不一致性明显较低，发生率比（IRR）分别为 0.65（CI=0.44，0.96）和 0.41（CI=0.23，0.75）。在健康项目中，参与者的认知功能越好，不一致性越低，IRR 为 0.85（CI=0.76，0.94）。
结论
人口统计学信息的一致性最受性别和信息报告者与参与者关系的影响。认知功能水平与健康信息的一致性最相关。
临床试验
gov 标识符 NCT03403257。
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