Mascellino M T, Lorenzi A, Bonanni M, Iegri F
Drugs Exp Clin Res. 1986;12(4):319-23.
A comparative study of the in vitro activity of norfloxacin was performed versus that of aminoglycosides, pipemidic acid, tetracycline and chloramphenicol. These antibiotics are the most commonly used antimicrobial agents in the treatment of enteric and urinary tract infections. Results obtained with norfloxacin against Gram-negative isolates tested were very encouraging. MIC values for the Enterobacteriaceae were less than or equal to 0.47 mcg/ml, and for Pseudomonas and Acinetobacter less than or equal to 32.5 mcg/ml. The activity of norfloxacin against Pseudomonas was inferior to that of amikacin, but superior to that of gentamicin. In association with aminoglycosides, norfloxacin proved to be most useful in the treatment of urinary tract infections, while norfloxacin associated with tetracycline and chloramphenicol did not give satisfactory results in the treatment of enteric infections.
对诺氟沙星与氨基糖苷类、吡哌酸、四环素和氯霉素的体外活性进行了比较研究。这些抗生素是治疗肠道和尿路感染最常用的抗菌药物。诺氟沙星对测试的革兰氏阴性菌分离株所获结果非常令人鼓舞。肠杆菌科细菌的最低抑菌浓度（MIC）值小于或等于0.47微克/毫升，假单胞菌属和不动杆菌属的MIC值小于或等于32.5微克/毫升。诺氟沙星对假单胞菌的活性低于阿米卡星，但高于庆大霉素。与氨基糖苷类联合使用时，诺氟沙星在治疗尿路感染方面被证明最为有效，而诺氟沙星与四环素和氯霉素联合使用在治疗肠道感染方面未取得满意结果。
