Jasinski D R, Preston K L
Drug Alcohol Depend. 1986 May;17(1):1-13. doi: 10.1016/0376-8716(86)90031-1.
Combinations of morphine and d-amphetamine have been shown to be more effective in relieving pathological and experimental pain with fewer side effects than morphine alone. Subjective, physiological and behavioral effects of the combination were assessed in the present study to determine whether the abuse liability of the combination might also be enhanced. Single intramuscular doses of morphine and d-amphetamine alone and in combination were tested under double-blind conditions in 10 adult, male, non-dependent substance abusers. Morphine and amphetamine alone increased scores on subjective effect measures including the Morphine-Benzedrine Group (MBG) (euphoria) and liking scales. In general, the combination produced greater euphoria than that produced by either drug alone. In contrast, many physiological effects of the drugs were mutually antagonized. Thus, the combination of morphine and d-amphetamine has a greater potential to be abused because of the additive euphoria and a lessening of side effects.
已表明，与单独使用吗啡相比，吗啡与右旋苯丙胺联合使用在减轻病理性疼痛和实验性疼痛方面更有效，且副作用更少。本研究评估了该联合用药的主观、生理和行为效应，以确定其滥用可能性是否也会增加。在双盲条件下，对10名成年男性非依赖性药物滥用者进行了测试，单独及联合给予单剂量肌肉注射吗啡和右旋苯丙胺。单独使用吗啡和苯丙胺会提高主观效应指标的得分，包括吗啡 - 苯丙胺组（MBG）（欣快感）和喜好量表。总体而言，联合用药产生的欣快感比单独使用任何一种药物都更强。相比之下，两种药物的许多生理效应相互拮抗。因此，由于欣快感叠加且副作用减轻，吗啡和右旋苯丙胺联合使用有更大的被滥用可能性。
