Jasinski D R, Preston K L
Psychopharmacology (Berl). 1987;91(3):273-8. doi: 10.1007/BF00518176.
Nefopam is a non-opioid analgesic reported to have some stimulant properties. The subjective, behavioral and physiological effects of nefopam, morphine and d-amphetamine were compared in seven non-dependent substance abusers to assess the abuse potential of nefopam. Morphine and d-amphetamine had significant effects on a number of measures generally consistent with the effects of drugs of the opioid and psychomotor stimulant drug classes. Subjects correctly discriminated between morphine and d-amphetamine. Nefopam was most frequently identified by subjects as being amphetamine-like, though several measures indicated that nefopam produced some sedation. Little or no "liking" of the effects of nefopam was reported by subjects. Overall, nefopam was one fifth as potent as morphine and one quarter as potent as d-amphetamine in producing subjective and physiological effects. The results indicate that nefopam is neither entirely morphine-like nor d-amphetamine-like. In our opinion, nefopam has a lesser potential to be abused than morphine or d-amphetamine.
奈福泮是一种据报道具有某些兴奋特性的非阿片类镇痛药。在7名非依赖性药物滥用者中比较了奈福泮、吗啡和右旋苯丙胺的主观、行为和生理效应，以评估奈福泮的滥用潜力。吗啡和右旋苯丙胺对一些指标有显著影响，这些影响总体上与阿片类药物和精神运动性兴奋药物类别的药物效应一致。受试者能够正确区分吗啡和右旋苯丙胺。受试者最常将奈福泮识别为类似苯丙胺，不过一些指标表明奈福泮会产生一些镇静作用。受试者报告对奈福泮的效应几乎没有或根本没有“喜好”。总体而言，在产生主观和生理效应方面，奈福泮的效力仅为吗啡的五分之一、右旋苯丙胺的四分之一。结果表明，奈福泮既不完全类似吗啡，也不完全类似右旋苯丙胺。我们认为，奈福泮被滥用的可能性比吗啡或右旋苯丙胺小。
