Berg Anna Korsgaard, Grauslund Annemarie Cecilie, Nørgaard Kirsten, Thorsen Steffen Ullitz, Zachariae Claus, Halling Anne-Sofie, Jakasa Ivone, Kezic Sanja, Svensson Jannet, Thyssen Jacob P
Department of Pediatrics, Herlev and Gentofte Hospital, Herlev, Denmark.
Copenhagen University Hospital - Steno Diabetes Center Copenhagen, Herlev, Denmark.
JID Innov. 2023 Mar 27;3(4):100200. doi: 10.1016/j.xjidi.2023.100200. eCollection 2023 Jul.
Contact dermatitis because of use of diabetes devices is frequent in individuals with type 1 diabetes (TD1), especially in the pediatric age group, but the putative role of a constitutional impaired skin barrier in persons with TD1 is unclear. This study examined the skin barrier function by the measurement of natural moisturizing factor and free cytokines collected through skin tape strips, as well as biophysical markers and the skin microbiome, in persons with TD1 than to age- and sex-matched healthy controls. All measurements were done in nonlesional skin. We found that the skin barrier function was similar in children and adolescents with TD1 than to controls but found that the beta-diversity of skin microbiome at the buttock differed between the two groups. We conclude that individuals with TD1 have normal skin barrier function, and that the increased occurrence of contact dermatitis following pump and sensor use is explained by exogenous factors.
1型糖尿病（TD1）患者因使用糖尿病设备而发生接触性皮炎很常见，尤其是在儿童年龄组，但TD1患者先天性皮肤屏障受损的假定作用尚不清楚。本研究通过测量通过皮肤胶带条收集的天然保湿因子和游离细胞因子，以及生物物理标志物和皮肤微生物群，对TD1患者与年龄和性别匹配的健康对照者的皮肤屏障功能进行了检测。所有测量均在非皮损皮肤上进行。我们发现，TD1儿童和青少年的皮肤屏障功能与对照组相似，但发现两组臀部皮肤微生物群的β多样性存在差异。我们得出结论，TD1患者具有正常的皮肤屏障功能，泵和传感器使用后接触性皮炎发生率增加是由外部因素引起的。
