Department of Dermatology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, #10, 63-ro, Yeongdeungpo-gu, Seoul 07345, Korea.
Int J Mol Sci. 2022 Oct 28;23(21):13071. doi: 10.3390/ijms232113071.
Human skin is the largest organ and serves as the first line of defense against environmental factors. The human microbiota is defined as the total microbial community that coexists in the human body, while the microbiome refers to the collective genome of these microorganisms. Skin microbes do not simply reside on the skin but interact with the skin in a variety of ways, significantly affecting the skin barrier function. Here, we discuss recent insights into the symbiotic relationships between the microbiome and the skin barrier in physical, chemical, and innate/adaptive immunological ways. We discuss the gut-skin axis that affects skin barrier function. Finally, we examine the effects of microbiome dysbiosis on skin barrier function and the role of these effects in inflammatory skin diseases, such as acne, atopic dermatitis, and psoriasis. Microbiome cosmetics can help restore skin barrier function and improve these diseases.
人体皮肤是最大的器官，是抵御环境因素的第一道防线。人类微生物组被定义为共存于人体内的微生物群落，而微生物组则指这些微生物的集体基因组。皮肤微生物不仅存在于皮肤表面，还以多种方式与皮肤相互作用，显著影响皮肤屏障功能。在这里，我们讨论了微生物组与皮肤屏障之间在物理、化学和先天/适应性免疫方面的共生关系的最新见解。我们讨论了影响皮肤屏障功能的肠-皮轴。最后，我们研究了微生物组失调对皮肤屏障功能的影响，以及这些影响在痤疮、特应性皮炎和银屑病等炎症性皮肤病中的作用。微生物组化妆品可以帮助恢复皮肤屏障功能并改善这些疾病。
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