Kouidhi Soumaya, Zidi Oumaima, Belkhiria Zeineb, Rais Henda, Ayadi Aida, Ben Ayed Farhat, Mosbah Amor, Cherif Ameur, El Gaaied Amel Ben Ammar
Laboratory BVBGR-LR11ES31, Biotechnopole Sidi Thabet, University Manouba, ISBST, Ariana 2020, Tunisia.
Association Tunisienne de Lutte contre le Cancer (ATCC), Tunis, Tunisia.
Explor Target Antitumor Ther. 2023;4(2):240-265. doi: 10.37349/etat.2023.00132. Epub 2023 Apr 26.
It is now well-acknowledged that microbiota has a profound influence on both human health and illness. The gut microbiota has recently come to light as a crucial element that influences cancer through a variety of mechanisms. The connections between the microbiome and cancer therapy are further highlighted by a number of preclinical and clinical evidence, suggesting that these complicated interactions may vary by cancer type, treatment, or even by tumor stage. The paradoxical relationship between gut microbiota and cancer therapies is that in some cancers, the gut microbiota may be necessary to maintain therapeutic efficacy, whereas, in other cancers, gut microbiota depletion significantly increases efficacy. Actually, mounting research has shown that the gut microbiota plays a crucial role in regulating the host immune response and boosting the efficacy of anticancer medications like chemotherapy and immunotherapy. Therefore, gut microbiota modulation, which aims to restore gut microbial balance, is a viable technique for cancer prevention and therapy given the expanding understanding of how the gut microbiome regulates treatment response and contributes to carcinogenesis. This review will provide an outline of the gut microbiota's role in health and disease, along with a summary of the most recent research on how it may influence the effectiveness of various anticancer medicines and affect the growth of cancer. This study will next cover the newly developed microbiota-targeting strategies including prebiotics, probiotics, and fecal microbiota transplantation (FMT) to enhance anticancer therapy effectiveness, given its significance.
如今，微生物群对人类健康和疾病都有着深远影响已得到广泛认可。肠道微生物群最近成为一个关键因素，它通过多种机制影响癌症。一些临床前和临床证据进一步凸显了微生物组与癌症治疗之间的联系，这表明这些复杂的相互作用可能因癌症类型、治疗方法甚至肿瘤阶段而异。肠道微生物群与癌症治疗之间的矛盾关系在于，在某些癌症中，肠道微生物群可能是维持治疗效果所必需的，而在其他癌症中，肠道微生物群的减少会显著提高疗效。实际上，越来越多的研究表明，肠道微生物群在调节宿主免疫反应以及提高化疗和免疫疗法等抗癌药物的疗效方面发挥着关键作用。因此，鉴于对肠道微生物组如何调节治疗反应以及在致癌过程中的作用的认识不断加深，旨在恢复肠道微生物平衡的肠道微生物群调节是一种可行的癌症预防和治疗技术。本综述将概述肠道微生物群在健康和疾病中的作用，并总结其如何影响各种抗癌药物疗效以及影响癌症生长的最新研究。鉴于其重要性，本研究接下来将涵盖新开发的针对微生物群的策略，包括益生元、益生菌和粪便微生物群移植（FMT），以提高抗癌治疗效果。
