与原发性骨髓B细胞淋巴瘤相关的系统性骨硬化症。

Systemic osteosclerosis associated with primary bone marrow B-cell lymphoma.

作者信息

Ozaki Shuji, Iima Tsutomu, Sekimoto Etsuko, Shibata Hironobu, Shigekiyo Toshio, Higuchi Yukio, Hirose Takanori

机构信息

Department of Hematology Tokushima Prefecture Central Hospital Tokushima Japan.

Department of Cardiovascular Medicine Tokushima Prefecture Central Hospital Tokushima Japan.

出版信息

EJHaem. 2023 Feb 5;4(2):483-487. doi: 10.1002/jha2.652. eCollection 2023 May.

DOI:10.1002/jha2.652

PMID:37206285

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10188472/

Abstract

Systemic osteosclerosis is a rare complication of hematological malignancies. Primary myelofibrosis and acute megakaryocytic leukemia are known as underlying diseases; however, lymphoid tumors have rarely been reported. Here we describe a case of a 50-year-old man with severe systemic osteosclerosis associated with primary bone marrow B-cell lymphoma. Analysis of bone metabolic markers revealed a high turnover of bone metabolism and an increase in serum osteoprotegerin levels. These results suggest the involvement of osteoprotegerin in the pathogenesis of osteosclerosis associated with hematological malignancies.

摘要

系统性骨硬化是血液系统恶性肿瘤的一种罕见并发症。原发性骨髓纤维化和急性巨核细胞白血病被认为是潜在疾病；然而，淋巴肿瘤很少被报道。在此，我们描述一例50岁男性患者，其患有与原发性骨髓B细胞淋巴瘤相关的严重系统性骨硬化。骨代谢标志物分析显示骨代谢转换率高且血清骨保护素水平升高。这些结果提示骨保护素参与了与血液系统恶性肿瘤相关的骨硬化的发病机制。