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一名接受伊马替尼治疗胃肠道间质瘤(GIST)的患者发生自发性非创伤性纵隔血肿。

Spontaneous Non-Traumatic Mediastinal Hematoma in a Patient on Imatinib Therapy for a Gastrointestinal Stromal Tumor (GIST).

作者信息

Aziz Rida, Khan Azeem, Yousefi Maryam, Khetani Shivani, Choudhry Hammad

机构信息

Internal Medicine, William Carey University College of Osteopathic Medicine, Hattiesburg, USA.

Internal Medicine, Bayonne Medical Center, Bayonne, USA.

出版信息

Cureus. 2023 Apr 17;15(4):e37701. doi: 10.7759/cureus.37701. eCollection 2023 Apr.

DOI:10.7759/cureus.37701
PMID:37206503
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10191238/
Abstract

Mediastinal hematomas are thoracic complications often resulting from direct trauma or aortic dissections. Spontaneous non-traumatic mediastinal hematomas are rare. We present a case of spontaneous non-traumatic mediastinal hematoma in a patient on Imatinib therapy for a gastrointestinal stromal tumor (GIST). A 67-year-old female presented to the ER with the chief complaint of constant sharp right shoulder pain that progressed to her chest. The patient was not on any anticoagulants and had not complained of shortness of breath. Under suspicion of a pulmonary embolism, a CT chest scan was performed, and a diagnosis of non-traumatic anterior mediastinal hematoma was confirmed. This case may warrant further investigation into the links between Imatinib use and the formation of mediastinal hematomas.

摘要

纵隔血肿是一种胸部并发症,常由直接创伤或主动脉夹层引起。自发性非创伤性纵隔血肿较为罕见。我们报告一例在接受伊马替尼治疗胃肠道间质瘤(GIST)的患者中发生的自发性非创伤性纵隔血肿。一名67岁女性因持续的右肩部剧痛并蔓延至胸部为主诉就诊于急诊室。该患者未服用任何抗凝剂,也未诉有气短症状。因怀疑肺栓塞,进行了胸部CT扫描,确诊为非创伤性前纵隔血肿。该病例可能需要进一步研究伊马替尼的使用与纵隔血肿形成之间的联系。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7449/10191238/439c10e48880/cureus-0015-00000037701-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7449/10191238/16c3749aa02b/cureus-0015-00000037701-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7449/10191238/d6c7356f7099/cureus-0015-00000037701-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7449/10191238/b11845e3a11c/cureus-0015-00000037701-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7449/10191238/439c10e48880/cureus-0015-00000037701-i04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7449/10191238/16c3749aa02b/cureus-0015-00000037701-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7449/10191238/d6c7356f7099/cureus-0015-00000037701-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7449/10191238/b11845e3a11c/cureus-0015-00000037701-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7449/10191238/439c10e48880/cureus-0015-00000037701-i04.jpg

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Int J Surg Case Rep. 2017;39:221-224. doi: 10.1016/j.ijscr.2017.08.040. Epub 2017 Aug 23.
2
Subcapsular Liver Hematoma in Metastatic GIST Complicating Imatinib (Gleevec) Therapy.转移性胃肠道间质瘤(GIST)患者在接受伊马替尼(格列卫)治疗时并发肝包膜下血肿
Radiol Case Rep. 2015 Dec 7;2(4):53. doi: 10.2484/rcr.2007.v2i4.53. eCollection 2007.
3
Subdural hematoma in a patient taking imatinib for GIST: a case report and discussion of risk with other chemotherapeutics.
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Anticancer Drugs. 2016 Mar;27(3):259-63. doi: 10.1097/CAD.0000000000000325.
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Imatinib mesylate as add-on therapy for pulmonary arterial hypertension: results of the randomized IMPRES study.甲磺酸伊马替尼作为肺动脉高压的附加治疗:随机 IMPRES 研究的结果。
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Traumatic rupture of the false lumen in a patient with preexisting chronic dissection of the descending thoracic aorta.一名患有慢性降主动脉夹层的患者出现创伤性假腔破裂。
Gen Thorac Cardiovasc Surg. 2011 Aug;59(8):559-62. doi: 10.1007/s11748-010-0694-8. Epub 2011 Aug 18.
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