Xuan Keh Min, Bakar Nurhidanatasha Abu, Fadzli Mustaffa Khairul Mohd, Azlan Maryam
School of Health Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.
Cent Eur J Immunol. 2023;48(1):54-62. doi: 10.5114/ceji.2023.126650. Epub 2023 Apr 13.
Malaria remains one of the most common human infections worldwide. In endemic areas, malaria is a leading cause of morbidity and mortality and it imposes significant socioeconomic burdens on the people affected. Monocytes are part of the immune system controlling parasite burden and protecting the host against malaria infection. Monocytes play their protective roles against malaria via phagocytosis, cytokine production and antigen presentation. Though monocytes are crucial for clearance of malaria infection, they have also been shown to cause adverse clinical outcomes. In this review, we discuss recent findings regarding the role of monocytes in malaria via mechanisms such as parasite detection and clearance, pro-inflammatory activities, and activation of other immune components. We also highlight the role of different monocyte subsets, and other myeloid cells that are involved in malaria infection. However, more investigations are required in order to explore the exact roles of these monocytes in malaria infection.
疟疾仍然是全球最常见的人类感染之一。在流行地区，疟疾是发病和死亡的主要原因，给受影响人群带来了巨大的社会经济负担。单核细胞是免疫系统的一部分，可控制寄生虫负荷并保护宿主免受疟疾感染。单核细胞通过吞噬作用、细胞因子产生和抗原呈递发挥抗疟疾的保护作用。虽然单核细胞对于清除疟疾感染至关重要，但它们也被证明会导致不良临床结果。在本综述中，我们通过寄生虫检测和清除、促炎活性以及其他免疫成分的激活等机制，讨论了关于单核细胞在疟疾中作用的最新发现。我们还强调了不同单核细胞亚群以及参与疟疾感染的其他髓系细胞的作用。然而，为了探索这些单核细胞在疟疾感染中的确切作用，还需要更多的研究。
