多发性硬化症与乳腺癌风险：观察性研究和孟德尔随机化研究的荟萃分析
Multiple sclerosis and breast cancer risk: a meta-analysis of observational and Mendelian randomization studies.
作者信息
Fang Tian, Zhang Zhihao, Zhou Huijie, Wu Wanchun, Zou Liqun
机构信息
Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, China.
Department of Thyroid Breast Surgery, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi, China.
出版信息
Front Neuroinform. 2023 May 3;17:1154916. doi: 10.3389/fninf.2023.1154916. eCollection 2023.
BACKGROUND
Several observational studies have explored the relationships between multiple sclerosis (MS) and breast cancer; however, whether an association exists remains unknown.
METHODS
We conducted a meta-analysis of observational studies and Mendelian randomization (MR) based on genetic variants to identify the relationship between MS and breast cancer. The observational studies were searched from PubMed, Embase, Web of Science, and Scopus to assess the relationship between MS and breast cancer from inception to 07 Nov 2022. Moreover, we explored the association between genetically pre-disposed MS and breast cancer risk based on an MR study. The summary analysis for MS from two separate databases [International Multiple Sclerosis Genetics Consortium (IMSGC), FinnGen] and the summary analysis for breast cancer from Breast Cancer Association Consortium.
RESULTS
Fifteen cohort studies involving 173,565 female MS patients were included in this meta-analysis. The correlation between MS and breast cancer was not statistically significant [relative ratio (RR) = 1.08, 95% confidence interval (CI) = 0.99-1.17]. In the MR analysis, we did not observe causal associations of genetically determined MS with breast cancer and its subtypes from both the IMSGC and FinnGen datasets.
CONCLUSION
The meta-analysis of observational and MR based on genetic variants does not support the correlation between MS and breast cancer.
背景
多项观察性研究探讨了多发性硬化症（MS）与乳腺癌之间的关系；然而，两者之间是否存在关联仍不清楚。
方法
我们对观察性研究和基于基因变异的孟德尔随机化（MR）进行了荟萃分析，以确定MS与乳腺癌之间的关系。从PubMed、Embase、Web of Science和Scopus检索观察性研究，以评估从研究开始至2022年11月7日MS与乳腺癌之间的关系。此外，我们基于一项MR研究探讨了遗传易感性MS与乳腺癌风险之间的关联。对来自两个独立数据库[国际多发性硬化症遗传学联盟（IMSGC）、芬兰基因组计划（FinnGen）]的MS汇总分析以及来自乳腺癌协会联盟的乳腺癌汇总分析。
结果
本荟萃分析纳入了15项队列研究，涉及173,565名女性MS患者。MS与乳腺癌之间的相关性无统计学意义[相对比（RR）=1.08，95%置信区间（CI）=0.99-1.17]。在MR分析中，我们未观察到来自IMSGC和FinnGen数据集的遗传决定的MS与乳腺癌及其亚型之间存在因果关联。
结论
基于基因变异的观察性研究和MR的荟萃分析不支持MS与乳腺癌之间的相关性。
Zotero 插件