Wang Li, Deng Jing-Ya, Fan Xi-Yue, Yang Dan, Zhu Ping-Yu, Wang Xiao-Ming
Department of Urology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Department of Neurology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Front Oncol. 2024 Jan 4;13:1323812. doi: 10.3389/fonc.2023.1323812. eCollection 2023.
Numerous observational studies have investigated the risk of prostate cancer (PCa) in patients diagnosed with Parkinson's Disease (PD). However, the existence of a definitive association remains uncertain.
Systematic searches were performed on PubMed, Web of Science, Scopus, and Google Scholar for studies published up to October 1, 2023. For Mendelian randomized (MR) causal inference, we employed pooled data from the IPDGC and PRACTICAL Consortium. The inverse variance weighted (IVW) method served as the principal technique for estimating odds ratios (ORs) and 95% confidence intervals (CIs) for the associations under investigation.
Cumulative analysis of nine studies revealed no significant association between patients diagnosed with PD and the subsequent incidence of PCa ([relative ratio] RR = 0.89, 95%CI = 0.73 to 1.08, P = 0.237). However, subgroup analyses indicated a reduced occurrence of PCa in Caucasian patients with PD (RR = 0.81, 95%CI = 0.69 to 0.95, P = 0.011). MR analyses failed to establish a significant link between increased genetic susceptibility to PD and the risk of PCa (IVW OR = 1.025, 95%CI = 0.997 to 1.054, P = 0.082). Sensitivity analyses further corroborated the robustness of these results.
Both observational meta-analysis and MR analysis based on genetic variation do not support an association between PD patients and the subsequent risk of PCa. Further research is warranted to unravel the potential underlying mechanisms linking these two diseases.
https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023473527.
众多观察性研究调查了被诊断为帕金森病（PD）的患者患前列腺癌（PCa）的风险。然而，二者之间是否存在明确关联仍不确定。
在PubMed、科学网、Scopus和谷歌学术上进行系统检索，查找截至2023年10月1日发表的研究。对于孟德尔随机化（MR）因果推断，我们采用了国际帕金森病基因组学联合会（IPDGC）和实用联盟（PRACTICAL Consortium）的汇总数据。逆方差加权（IVW）方法是估计所研究关联的比值比（OR）和95%置信区间（CI）的主要技术。
对9项研究的累积分析显示，被诊断为PD的患者与随后PCa的发病率之间无显著关联（[相对比率]RR = 0.89，95%CI = 0.73至1.08，P = 0.237）。然而，亚组分析表明，患有PD的白种人患者中PCa的发生率降低（RR = 0.81，95%CI = 0.69至0.95，P = 0.011）。MR分析未能确定PD遗传易感性增加与PCa风险之间存在显著联系（IVW OR = 1.025，95%CI = 0.997至1.054，P = 0.082）。敏感性分析进一步证实了这些结果的稳健性。
基于遗传变异的观察性荟萃分析和MR分析均不支持PD患者与随后PCa风险之间存在关联。有必要进行进一步研究以阐明连接这两种疾病的潜在机制。
