Department of Radiology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
ACS Appl Mater Interfaces. 2023 May 31;15(21):25285-25299. doi: 10.1021/acsami.3c00865. Epub 2023 May 19.
Pancreatic cancer (PC) is one of the most malignant cancers that develops rapidly and carries a poor prognosis. Synergistic cancer therapy strategy could enhance the clinical efficacy compared to either treatment alone. In this study, gold nanorods (AuNRs) were used as siRNA delivery vehicles to interfere with the oncogenes of KRAS. In addition, AuNRs were one of anisotropic nanomaterials that can absorb near-infrared (NIR) laser and achieve rapid photothermal therapy for malignant cancer cells. Modification of the erythrocyte membrane and antibody Plectin-1 occurred on the surface of the AuNRs, making them a promising target nanocarrier for enhancing antitumor effects. As a result, biomimetic nanoprobes presented advantages in biocompatibility, targeting capability, and drug-loading efficiency. Moreover, excellent antitumor effects have been achieved by synergistic photothermal/gene treatment. Therefore, our study would provide a general strategy to construct a multifunctional biomimetic theranostic multifunctional nanoplatform for preclinical studies of PC.
胰腺癌（PC）是一种恶性程度较高的癌症，其发展迅速，预后不良。协同癌症治疗策略可以比单独治疗更能提高临床疗效。在本研究中，金纳米棒（AuNRs）被用作 siRNA 输送载体，以干扰 KRAS 癌基因。此外，AuNRs 是一种各向异性纳米材料，能够吸收近红外（NIR）激光，实现恶性癌细胞的快速光热治疗。AuNRs 表面发生了红细胞膜和抗体 Plectin-1 的修饰，使其成为一种很有前途的靶向纳米载体，可增强抗肿瘤效果。因此，仿生纳米探针在生物相容性、靶向能力和载药效率方面具有优势。此外，通过协同光热/基因治疗实现了优异的抗肿瘤效果。因此，我们的研究将为构建用于 PC 临床前研究的多功能仿生治疗多功能纳米平台提供一种通用策略。
