Department of Thyroid and Breast Surgery, Medical Research Institute, Frontier Science Center for Immunology and Metabolism, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China.
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Endocrinology. 2023 Apr 17;164(6). doi: 10.1210/endocr/bqad080.
α-Ketoglutarate (αKG)-dependent dioxygenases are a superfamily of enzymes that require oxygen, reduced iron, and αKG for their catalytic functions. Therefore, they have the potential to sense the availabilities of oxygen, iron, and specific metabolites, including αKG and its structurally related metabolites. These enzymes play essential roles in various biological processes, including cellular adaptation to hypoxia, epigenetic and epitranscriptomic regulation of gene expression, and metabolic reprogramming. Many αKG-dependent dioxygenases are dysregulated in cancer pathogenesis. Herein, we review how they are regulated and function in breast cancer, which may offer new therapeutic intervention strategies for targeting this family of enzymes.
α-酮戊二酸（αKG）依赖性双加氧酶是一个超家族的酶，它们的催化功能需要氧气、还原态铁和 αKG。因此，它们有可能感知氧气、铁和特定代谢物（包括 αKG 和其结构相关代谢物）的可用性。这些酶在各种生物过程中发挥着重要作用，包括细胞对缺氧的适应、基因表达的表观遗传和转录后调控以及代谢重编程。许多 αKG 依赖性双加氧酶在癌症发病机制中失调。本文综述了它们在乳腺癌中的调控和功能，这可能为靶向这一家族酶提供新的治疗干预策略。
