经尿道导管对男性尿流压力-流量关系的影响：计算流体动力学研究。
Influence of transurethral catheters on urine pressure-flow relationships in males: A computational fluid-dynamics study.
机构信息
Department of Industrial Engineering, University of Padova, Padova, Italy; Centre of Mechanics of Biological Materials, University of Padova, Padova, Italy.
Centre of Mechanics of Biological Materials, University of Padova, Padova, Italy; Department of Civil, Environmental and Architectural Engineering, University of Padova, Padova, Italy; Department of Biomedical Sciences, University of Padova, Padova, Italy.
出版信息
Comput Methods Programs Biomed. 2023 Aug;238:107594. doi: 10.1016/j.cmpb.2023.107594. Epub 2023 May 9.
BACKGROUND AND OBJECTIVE
In the field of urology, the pressure-flow study (PFS) is an essential urodynamics practise which requires the patient's transurethral catheterization during the voiding phase of micturition to evaluate the functionality of the lower urinary tract (LUT) and reveal the pathophysiology of its dysfunctionality. However, the literature evidences confusion regarding the interference of the catheterization on the urethral pressure-flow behaviour.
METHODS
The present research study represents the first Computational Fluid-Dynamics (CFD) approach to this urodynamics issue, analysing the influence of a catheter in the male LUT through case studies which included the inter-individual and intra-individual dependence. A set of four three dimensional (3D) models of the male LUT, different in urethral diameters, and a set of three 3D models of the transurethral catheter, diverse in calibre, were developed leading to 16 CFD non-catheterized either catheterized configurations, to describe the typical micturition scenario considering both urethra and catheter characteristics.
RESULTS
The developed CFD simulations showed that the urine flow field during micturition was influenced by the urethral cross-sectional area and each catheter determined a specific decrease in flow rate if compared to the relative free uroflow.
CONCLUSIONS
In-silico methods allow to analyse relevant urodynamics aspects, which could not be investigated in vivo, and may support the clinical PFS to reduce uncertainty on urodynamic diagnosis.
背景与目的
在泌尿科领域，压力-流率研究（PFS）是一种基本的尿动力学实践，需要患者在排尿阶段进行经尿道导尿，以评估下尿路（LUT）的功能，并揭示其功能障碍的病理生理学。然而，文献中对于导尿对尿道压力-流率行为的干扰存在混淆。
方法
本研究代表了对这一尿动力学问题的首次计算流体动力学（CFD）方法，通过包括个体间和个体内依赖性的病例研究来分析导尿管对男性 LUT 的影响。我们开发了一组四个不同尿道直径的男性 LUT 的三维（3D）模型，以及一组三个不同口径的经尿道导尿管的 3D 模型，共产生了 16 个非导尿和导尿的 CFD 配置，以描述考虑尿道和导管特征的典型排尿场景。
结果
开发的 CFD 模拟表明，在排尿过程中尿液流场受到尿道横截面积的影响，与相对自由尿流相比，每个导管都会导致特定的流速下降。
结论
计算方法可以分析体内无法研究的相关尿动力学方面，并可能支持临床 PFS 以减少对尿动力学诊断的不确定性。
Zotero 插件