Zawad J S, Sulser F
Eur J Pharmacol. 1986 May 13;124(1-2):157-60. doi: 10.1016/0014-2999(86)90136-6.
The effect of l-isoproterenol on S-adenosyl-L-methionine (Adomet)-mediated phospholipid methylation in rat brain cortex was examined. Under conditions which favor the activity of methyltransferase I (i.e. low Adomet), formation of phosphatidyl-N-methylethanolamine was inhibited by l-isoproterenol. On the other hand, methyltransferase II activity (i.e. high Adomet) was stimulated by l-isoproterenol. The results suggest that Adomet may play a regulatory role in the response of phospholipid methyltransferases to catecholamines in brain.
研究了L-异丙肾上腺素对大鼠脑皮质中S-腺苷-L-甲硫氨酸（Adomet）介导的磷脂甲基化的影响。在有利于甲基转移酶I活性的条件下（即低Adomet），L-异丙肾上腺素抑制了磷脂酰-N-甲基乙醇胺的形成。另一方面，L-异丙肾上腺素刺激了甲基转移酶II的活性（即高Adomet）。结果表明，Adomet可能在脑中磷脂甲基转移酶对儿茶酚胺的反应中起调节作用。
