[Use of malate and NAD for the correction of the blood supply and oxygen balance of the acutely ischemic myocardium].

The experiments on cats under the conditions of acute myocardial ischemia showed that malate (20 and 100 mg/kg) and NAD (0.2 and 2 mg/kg) are able of increasing the coronary blood flow against the background of insignificantly increased oxygen consumption by the heart. The combination of these drugs (malate 100 mg/kg + NAD 0.2 mg/kg) produces an increase in the coronary blood flow and a dramatic raise in cardiac oxygen consumption.