Vinogradova L F, Kharlitskaia E V, Avakumov V M, Obol'nikova E A, Samokhvalov G I
Farmakol Toksikol. 1986 May-Jun;49(3):52-4.
The effect of a single and 2-week administration of ubiquinone-9 on the blood coagulation system and the functional activity of platelets was studied in the experiments in vitro and in vivo on rats. It was shown that a single dose of 150 mg/kg of ubiquinone decreased adhesion and that of 5 mg/kg decreased aggregation of platelets. Both with a single and 2-week drug administration in doses of 5, 50 and 150 mg/kg an insignificant decrease of coagulability was observed.
在大鼠体内和体外实验中,研究了单次及连续2周给予辅酶Q9对血液凝固系统和血小板功能活性的影响。结果表明,单次给予150mg/kg辅酶Q9可降低血小板黏附,给予5mg/kg可降低血小板聚集。给予5、50和150mg/kg的药物单次及连续2周给药后,均观察到凝血性有轻微降低。