School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
School of Biodiversity, One Health, and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
Environ Toxicol Pharmacol. 2023 Jun;100:104152. doi: 10.1016/j.etap.2023.104152. Epub 2023 May 18.
Environmental chemical (EC) exposure may be impacting male reproductive health. The translationally relevant biosolids treated pasture (BTP) sheep model was used to investigate gestational low-level EC mixture exposure on the testes of F1 male offspring. Adult rams from ewes exposed to BTP 1 month before and throughout pregnancy had more seminiferous tubules with degeneration and depletion of elongating spermatids, indicating possible "recovery" from previously reported testicular dysgenesis syndrome-like phenotype in neonatal and pre-pubertal BTP lambs. Expression of transcription factors CREB1 (neonatal) and BCL11A and FOXP2 (pre-pubertal) were significantly higher in the BTP exposed testes, with no changes seen in adults. Increased CREB1, which is crucial for testes development and regulation of steroidogenic enzymes, could be an adaptive response to gestational EC exposure to facilitate the phenotypic recovery. Overall, this demonstrates that testicular effects from gestational exposure to low-level mixtures of ECs can last into adulthood, potentially impacting fertility and fecundity.
环境化学物质（EC）暴露可能会影响男性生殖健康。本研究采用具有转化相关性的经生物固体处理牧场（BTP）绵羊模型，探究妊娠期低水平 EC 混合物暴露对 F1 雄性后代睾丸的影响。来自于在妊娠前一个月和整个妊娠期间暴露于 BTP 的母羊的成年公羊，其生精小管出现更多退化和伸长精子细胞耗竭，表明与新生儿和青春期前 BTP 羔羊的睾丸发育不良综合征样表型有关的“恢复”。转录因子 CREB1（新生儿）和 BCL11A 和 FOXP2（青春期前）的表达在 BTP 暴露的睾丸中显著升高，而在成年公羊中未见变化。CREB1 增加，对于睾丸发育和类固醇生成酶的调节至关重要，可能是对妊娠期 EC 暴露的适应性反应，以促进表型恢复。总的来说，这表明从妊娠期到低水平 EC 混合物的暴露可能会持续到成年期，从而影响生育能力和繁殖力。
