Khan Noor Muhammad, Scott Victoria, Ghasemzadeh-Hasankolaei Mohammad, Padmanabhan Vasantha, Vyas Arpita, Evans Neil P, Bellingham Michelle
School of Biodiversity One Health and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
Immunology and Immuno-bioengineering group, School of Life Sciences, University of Nottingham, UK.
Environ Toxicol Pharmacol. 2025 Apr;115:104669. doi: 10.1016/j.etap.2025.104669. Epub 2025 Mar 4.
Cardiovascular disease (CVD) is a leading cause of death that is sexually dimorphic. This study used an ovine model to investigate whether maternal exposure to an environmental chemical (EC) mixture (biosolids) prior to and throughout pregnancy, affected offspring cardiovascular (CV) structure and function in adulthood. CV function of male and female offspring from ewes grazed on either conventionally fertilised (control, C) or biosolids-treated pasture (B) was assessed. Males exhibited higher blood pressure compared to females with no significant effect of EC exposure. Heart rate variability in females suggested reduced autonomic regulation in the B group. EC-exposed males, but not females, showed significantly increased left ventricular dimensions, end-diastolic and systolic volumes, and cardiac output. The findings indicate sexually dimorphic effects of maternal EC mixture exposure on adult CV structure and function. Further studies are needed to explore the mechanisms and long-term implications of prenatal exposure to ECs on CV health.
心血管疾病（CVD）是导致死亡的主要原因，且存在性别差异。本研究使用绵羊模型来调查孕期及整个妊娠期母体暴露于环境化学物质（EC）混合物（生物固体）是否会影响成年后代的心血管（CV）结构和功能。评估了在传统施肥牧场（对照，C）或生物固体处理牧场（B）放牧的母羊所产雄性和雌性后代的CV功能。与雌性相比，雄性血压更高，且EC暴露无显著影响。雌性的心率变异性表明B组自主调节功能降低。暴露于EC的雄性而非雌性，其左心室尺寸、舒张末期和收缩末期容积以及心输出量显著增加。研究结果表明母体暴露于EC混合物对成年CV结构和功能存在性别差异效应。需要进一步研究以探索产前暴露于EC对CV健康的作用机制和长期影响。
