Briguglio F, Briguglio E, Di Marco V, Swat M, Materia G, Intilisano A
J Int Med Res. 1986;14(3):115-23. doi: 10.1177/030006058601400301.
Ten patients affected by occlusive arterial disease and presenting with skin lesions of the limbs were treated with buflomedil first i.v. and then orally, at a dosage of 600 mg/day. After a treatment period of 30 to 60 days, eight patients showed lesion regression with complete recovery; the remaining two patients dropped out of the study. The mechanism of action of buflomedil in healing skin lesions is also discussed.
十名患有闭塞性动脉疾病并伴有肢体皮肤病变的患者首先接受了静脉注射丁咯地尔治疗，然后口服，剂量为每日600毫克。经过30至60天的治疗期后，八名患者的病变出现消退并完全康复；其余两名患者退出了研究。文中还讨论了丁咯地尔治疗皮肤病变的作用机制。
