Mozzi E, Chiurazzi D, Spinola A, Annoni F, Germiniani R
J Int Med Res. 1985;13(6):317-21. doi: 10.1177/030006058501300603.
Fifty-three patients suffering from chronic arterial diseases of the lower limbs were treated with buflomedil, a vasoactive drug with vasodilating and hemorheological action on the microcirculation. The patients suffered from pain on walking or pain at rest; they were given 300 mg buflomedil orally twice a day for a period of about 2 months. The walking distance before pain onset was checked in all patients before and after the trial. Blood and plasma viscosity, haematocrit and fibrinogen and a Doppler velocimetry were also recorded. A significant improvement of the walking distance before pain onset was observed in nearly all patients, and in most patients the morphology of the velocity waves improved, too. No clear correlation between the positive clinical results and the hemorheological parameters studied could be observed.
53例患有下肢慢性动脉疾病的患者接受了丁咯地尔治疗，丁咯地尔是一种对微循环具有血管舒张和血液流变学作用的血管活性药物。这些患者存在行走时疼痛或静息痛；给予他们口服丁咯地尔300mg，每日两次，持续约2个月。在试验前后对所有患者检查疼痛发作前的行走距离。还记录了血液和血浆粘度、血细胞比容、纤维蛋白原以及多普勒测速。几乎所有患者疼痛发作前的行走距离都有显著改善，并且大多数患者速度波的形态也有所改善。未观察到阳性临床结果与所研究的血液流变学参数之间存在明显相关性。
