Concia E, Marone P, Moreo G C, Sardi C, Braschi R
J Int Med Res. 1986;14(3):137-41. doi: 10.1177/030006058601400304.
The kinetics of RV11 (propionyl erythromycin mercaptosuccinate) in serum and bronchial secretions was investigated in heterogeneous bronchopneumopathic patients requiring diagnostic bronchoscopy. A single oral dose, equivalent to 500 mg of erythromycin base, was administered to all patients and the bronchial secretion and plasma concentrations were determined after 2, 3 and 4 hr. The bronchial secretion and plasma levels consistently exceeded those reported previously for erythromycin per os, suggesting that RV11 may have an unusually high affinity for bronchial secretions in humans. The results of this study also suggested that RV11 might have different kinetics in bronchial secretions and serum, though further studies are required to provide definitive evidence.
在需要进行诊断性支气管镜检查的异质性支气管肺炎患者中，研究了RV11（丙酰基红霉素巯基琥珀酸酯）在血清和支气管分泌物中的动力学。对所有患者给予相当于500mg红霉素碱的单次口服剂量，并在2、3和4小时后测定支气管分泌物和血浆浓度。支气管分泌物和血浆水平始终超过先前报道的口服红霉素的水平，这表明RV11对人体支气管分泌物可能具有异常高的亲和力。这项研究的结果还表明，RV11在支气管分泌物和血清中的动力学可能不同，不过还需要进一步研究来提供确凿证据。
