红霉素在人支气管黏膜中的渗透。
The penetration of erythromycin into human bronchial mucosa.
作者信息
Mattie H, Hoogeterp J J, Kaajan J P, Hermans J
出版信息
Br J Clin Pharmacol. 1987 Aug;24(2):179-83. doi: 10.1111/j.1365-2125.1987.tb03159.x.
1 In this paper the pharmacokinetic relation between concentrations of erythromycin in plasma and in bronchial mucosa was established. 2 Sixteen patients undergoing bronchoscopy received 1 g erythromycin by continuous infusion in 30 min. 3 Two bronchial mucosal samples were taken from each patient sometime after drug administration. Concentrations were determined in the mucosal sample and in several plasma samples collected at different times before the mucosal sample. 4 Rate constants for the distribution between plasma and tissue were calculated on the basis of the assumption of passive diffusion of the free drug. 5 Mean values of the distribution rate constants, calculated by a nonlinear curve fitting procedure, were 2.40 h-1 for distribution from plasma to tissue and 1.28 h-1 for that from tissue to plasma. 6 These values correspond to a half-life for the distribution of the free drug of 33 min and a free fraction of the drug in mucosal tissue of 0.20.
- 本文建立了血浆和支气管黏膜中红霉素浓度之间的药代动力学关系。2. 16名接受支气管镜检查的患者在30分钟内通过持续输注接受了1克红霉素。3. 在给药后的某个时间从每位患者身上采集两份支气管黏膜样本。测定黏膜样本以及在采集黏膜样本之前不同时间采集的几份血浆样本中的浓度。4. 基于游离药物被动扩散的假设计算血浆与组织之间的分布速率常数。5. 通过非线性曲线拟合程序计算的分布速率常数的平均值，从血浆到组织的分布为2.40 h⁻¹，从组织到血浆的分布为1.28 h⁻¹。6. 这些值对应于游离药物分布的半衰期为33分钟，药物在黏膜组织中的游离分数为0.20。
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