Department of Otolaryngology, Guangzhou University of Traditional Chinese Medicine First Affiliated Hospital, Guangzhou, China.
The First School Of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.
Sci Rep. 2023 May 20;13(1):8181. doi: 10.1038/s41598-023-34848-8.
To compare the clinicopathologic characteristics of second primary squamous cell carcinoma (SPSCC) in patients with nasopharyngeal carcinoma (NPC) after intensity-modulated radiotherapy (IMRT) with that after radiotherapy (RT). From 49,021 patients with NPC who treated by definitive RT, we were able to identify 15 male patients with SPSCC after IMRT, and 23 male patients with SPSCC after RT. We examined the difference between groups. In IMRT group, 50.33% developed SPSCC within 3 years, whereas 56.52% developed SPSCC after more than 10 years in RT group. Receiving IMRT was related positively to an increased risk of SPSCC (HR = 4.25; P < 0.001). There was no significant correlation between receiving IMRT and the survival of SPSCC (P = 0.051). Receiving IMRT was related positively to an increased risk of SPSCC, and the latency was much shorter. A follow-up protocol, especially in the first three years, should be designed for NPC patients with IMRT.
比较调强放疗（IMRT）后和放疗（RT）后鼻咽癌（NPC）患者第二原发鳞状细胞癌（SPSCC）的临床病理特征。从接受根治性 RT 治疗的 49021 例 NPC 患者中，我们共鉴定出 15 例 IMRT 后发生 SPSCC 的男性患者和 23 例 RT 后发生 SPSCC 的男性患者。我们研究了两组间的差异。在 IMRT 组中，50.33%的患者在 3 年内发生 SPSCC，而在 RT 组中，56.52%的患者在 10 年以上发生 SPSCC。接受 IMRT 与 SPSCC 风险增加呈正相关（HR=4.25；P<0.001）。接受 IMRT 与 SPSCC 的生存无显著相关性（P=0.051）。接受 IMRT 与 SPSCC 风险增加呈正相关，潜伏期也明显缩短。对于接受 IMRT 的 NPC 患者，应设计随访方案，特别是在前 3 年。
