Yagihashi S, Sima A A
Diabetes. 1986 Jul;35(7):733-43. doi: 10.2337/diab.35.7.733.
Longitudinal electron-microscopic and morphometric studies of autonomic nerves containing predominantly parasympathetic fibers were undertaken in the spontaneously diabetic BB rat. Unmyelinated fibers of the diabetic vagus nerve and myelinated fibers of the penile nerve showed increased numbers of axonal glycogenosomes and axonal sequestration. Morphometric examination of myelinated and unmyelinated fibers of the vagus nerve revealed diminished fiber size compared with age-matched control animals. The distal myenteric nerve showed marked degenerative changes, whereas no structural changes could be demonstrated in intra-myenteric ganglion cells. These changes are similar to those described previously in somatic nerves of this model but different from those seen in sympathetic nerves of the diabetic BB rat.
对自发性糖尿病BB大鼠中主要含有副交感神经纤维的自主神经进行了纵向电子显微镜和形态计量学研究。糖尿病迷走神经的无髓纤维和阴茎神经的有髓纤维显示轴突糖原小体数量增加和轴突隔离。与年龄匹配的对照动物相比，迷走神经有髓和无髓纤维的形态计量学检查显示纤维尺寸减小。远端肌间神经呈现明显的退行性变化，而肌间神经节细胞未显示出结构变化。这些变化与先前在该模型的躯体神经中描述的变化相似，但与糖尿病BB大鼠交感神经中所见的变化不同。
