Yagihashi S, Sima A A
Am J Pathol. 1985 Oct;121(1):138-47.
Ultrastructural and morphometric studies were performed longitudinally to characterize the topographic distribution of autonomic neuropathy in the BB-rat. Four levels of predominantly sympathetic nerves were examined. Typical axonal dystrophic changes were consistently increased in diabetic rats and were found to be most severe in the prevertebral celiac ganglion, the mesenteric nerve, the superior cervical ganglion, and the paravertebral ganglion, in that order. Dystrophic changes were also demonstrated in postsynaptic dendrites. In addition, the diabetic mesenteric nerve displayed progressive nerve fiber atrophy and fiber loss. We conclude that dystrophic and degenerative axonopathy is a reproducible structural hallmark of diabetic sympathetic neuropathy. It does not appear to be an accentuation of an age-related phenomenon, but rather, it is caused by the persistent diabetic dysmetabolism.
进行了超微结构和形态计量学研究，以纵向表征BB大鼠自主神经病变的地形分布。检查了四个主要为交感神经的水平。典型的轴突营养不良性改变在糖尿病大鼠中持续增加，并且发现依次在椎前腹腔神经节、肠系膜神经、颈上神经节和椎旁神经节中最为严重。突触后树突也出现了营养不良性改变。此外，糖尿病肠系膜神经显示出进行性神经纤维萎缩和纤维丢失。我们得出结论，营养不良性和退行性轴突病是糖尿病性交感神经病变可重复的结构特征。它似乎不是与年龄相关现象的加重，而是由持续的糖尿病代谢紊乱引起的。
