Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Lasers Surg Med. 2023 Aug;55(6):528-535. doi: 10.1002/lsm.23681. Epub 2023 May 20.
Enlarged facial pores are visible topographic features of the skin that have been associated with cutaneous photoaging and increased sebum production. It has remained a common dermatologic concern, gaining a significant number of in-clinic consults. Available treatment modalities often operate on a single mode of action, consequently offering limited and short-term outcomes.
This study aimed to evaluate the long-term efficacy and safety of a nonablative monopolar radiofrequency (NMRF) for pore tightening and sebum output reduction in Thai patients.
Nineteen patients with enlarged pores underwent two sessions of NMRF treatments at 4-week intervals. The measurements of pore volume, skin texture, average pore size, sebum production, and skin elasticity were quantified using Antera® 3D imaging system, dermoscopic image analysis with ImageJ software, Sebumeter® and Cutometer®. Clinical evaluation by two dermatologists was done using blinded clinical photographs. All objective and subjective assessments were done at the baseline, a month after the first treatment, and during follow-up visits 1, 3, and 6 months after the last treatment. Adverse effects were also recorded during each visit.
Seventeen out of the 19 subjects completed the study protocol. The mean pore volume significantly reduced by 24% from the baseline at 1 month after the first treatment (p < 0.016). The pore volume continued to decrease by 34% and 38% a month (p < 0.001) and 6 months (p < 0.001) following the final treatment, respectively. Sebum excretion likewise significantly decreased from baseline by 39% (p = 0.002) and 36% (p < 0.001), 3 and 6 months after the second treatment, respectively. Skin texture and elasticity also significantly improved following two NMRF sessions. The objective assessments of the pore appearance corresponded to subjective clinical evaluations. The treatment was well-tolerated without significant side effects, such as dyspigmentation, textural alteration, and scarring.
NMRF appears to be effective and safe for the reduction of pore size and sebum production, with therapeutic outcomes persisting up to 6 months after two treatment sessions.
面部毛孔粗大是皮肤的可见地形特征，与皮肤光老化和皮脂分泌增加有关。这一直是一个常见的皮肤科问题，因此需要进行大量的门诊咨询。现有的治疗方法通常作用于单一的作用模式，因此提供的效果有限且短期。
本研究旨在评估非剥脱性单极射频（NMRF）治疗泰国患者毛孔紧致和减少皮脂分泌的长期疗效和安全性。
19 例毛孔粗大的患者在 4 周的间隔内接受了两次 NMRF 治疗。使用 Antera® 3D 成像系统、ImageJ 软件的皮肤镜图像分析、Sebumeter® 和 Cutometer® 对毛孔体积、皮肤纹理、平均毛孔大小、皮脂分泌和皮肤弹性进行量化。两名皮肤科医生通过盲法临床照片进行临床评估。所有客观和主观评估均在基线、第一次治疗后一个月以及最后一次治疗后 1、3 和 6 个月的随访期间进行。在每次就诊时还记录了不良反应。
19 名受试者中有 17 名完成了研究方案。第一次治疗后 1 个月，毛孔体积从基线平均减少 24%（p<0.016）。治疗结束后 1 个月（p<0.001）和 6 个月（p<0.001），毛孔体积分别继续减少 34%和 38%。皮脂分泌同样从基线显著减少 39%（p=0.002）和 36%（p<0.001），分别在第二次治疗后 3 个月和 6 个月。两次 NMRF 治疗后，皮肤纹理和弹性也显著改善。毛孔外观的客观评估与主观临床评估相对应。治疗耐受良好，无明显副作用，如色素沉着异常、质地改变和瘢痕形成。
NMRF 似乎对减少毛孔大小和皮脂分泌有效且安全，两次治疗后治疗效果可持续长达 6 个月。
